Evidence map›Paper›PMID 21553233›Full record

ReviewCellular and molecular life sciences : CMLS2011

Peptide antigens for gamma/delta T cells.

Willi K Born, Li Zhang, Maki Nakayama, Niyun Jin, Jennifer L Chain, Yafei Huang, M Kemal Aydintug, Rebecca L O'Brien

Open access · greenAbstract readReview
In one paragraph

Review in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Activation of Human Vδ2Journal of immunology (Baltimore, Md. : 1950) · 2020
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. Diversity of γδ T-cell antigens.Cellular & molecular immunology · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Willi K BornIntegrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA. bornw@njhealth.org
Li Zhang
Maki Nakayama
Niyun Jin
Jennifer L Chain
Yafei Huang
M Kemal Aydintug
Rebecca L O'Brien
University of Colorado Denver · USNational Jewish Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γδ T cells express adaptive antigen receptors encoded by rearranging genes. Their diversity is highest in the small region of TCR V-J junctions, especially in the δ chain, which should enable the γδ TCRs to distinguish differences in small epitopes. Indeed, recognition of small molecules, and of an epitope on a larger protein has been reported. Responses to small non-peptides known as phospho-antigens are multi-clonal yet limited to a single γδ T cell subset in humans and non-human primates. Responses to small peptides are multi-clonal or oligo-clonal, include more than one subset of γδ T cells, and occur in rodents and primates. However, less effort has been devoted to investigate the peptide responses. To settle the questions of whether peptides can be ligands for the γδ TCRs, and whether responses to small peptides might occur normally, peptide binding will have to be demonstrated, and natural peptide ligands identified.

Indexed as

AnimalsAntigensAntigens, BacterialEpitopes, T-LymphocyteHumansPeptidesProtein BindingReceptors, Antigen, T-Cell, gamma-deltaT-LymphocytesAntigensAntigens, BacterialEpitopes, T-LymphocytePeptidesReceptors, Antigen, T-Cell, gamma-delta

Identifiers

PMID21553233
PMCPMC11114491
OpenAlexW2075429912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.