SynthesisMolecular biology reports2012
Associations between interleukin-10 polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis.
Synthesis in Molecular biology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Associations between interleukin-10 polymorphisms and susceptibility to rheumatoid arthritis: a meta-analysis and meta-regression.Clinical rheumatology · 2018Pooled it
- Interleukin-10 promoter gene polymorphisms and susceptibility to asthma: a meta-analysis.PloS one · 2013Pooled it
- Associations between interleukin-10 polymorphisms and susceptibility to psoriasis: a meta-analysis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Pooled it
- Comparison of the efficacy and safety of olokizumab at different dosages in patients with active rheumatoid arthritis: a network meta-analysis of randomized controlled trials.Zeitschrift fur Rheumatologie · 2024Article
- Relative remission rates of Janus kinase inhibitors in comparison with adalimumab in patients with active rheumatoid arthritis: a network meta-analysis.Zeitschrift fur Rheumatologie · 2024Article
- Comparison of the efficacy and safety of tocilizumab, sarilumab, and olokizumab in patients with active rheumatoid arthritis: a network meta-analysis of randomized controlled trials.Zeitschrift fur Rheumatologie · 2024Article
- Comparative efficacy and safety of tofacitinib, baricitinib, upadacitinib, and filgotinib in active rheumatoid arthritis refractory to biologic disease-modifying antirheumatic drugs.Zeitschrift fur Rheumatologie · 2021Article
- Relative efficacy and safety of tofacitinib, baricitinib, upadacitinib, and filgotinib in comparison to adalimumab in patients with active rheumatoid arthritis.Zeitschrift fur Rheumatologie · 2020Article
- Polymorphisms of Pre-miR-499 rs3746444 T/C and Pre-miR-146a rs2910164 C/G in the Autoimmune Diseases of Rheumatoid Arthritis and Systemic Lupus Erythematosus in the West of Iran.Iranian journal of public health · 2020Article
- Genetic polymorphism in psoriasis and its meaning for the treatment efficacy in the future.Postepy dermatologii i alergologii · 2018Review
- Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis.Clinical and experimental immunology · 2016Article
- Pathologic patterns of interleukin 10 expression--a review.Biochemia medica · 2015Review
- Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications.World journal of orthopedics · 2014Review
- Gene polymorphisms that can predict response to anti-TNF therapy in patients with psoriasis and related autoimmune diseases.The pharmacogenomics journal · 2013Review
- Oral treatment with Hev b 13 prevents experimental arthritis in mice.Clinical and experimental immunology · 2012Article
- Combined promoter haplotypes of the IL10R genes are associated with protection against severe malaria in Gabonese children.Immunogenetics · 2012Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to determine whether the interleukin-10 (IL-10) polymorphisms confer susceptibility to rheumatoid arthritis (RA). A meta-analysis was conducted on the associations between the IL-10 -1082 G/A, -592 C/A, -892 C/T and IL-10.R polymorphisms and RA using; (1) allele contrast, (2) the recessive model, (3) the dominant model, and (4) the additive model. A total of 16 studies (19 comparisons) involving 2647 RA patients and 3383 controls were considered in the meta-analysis. Meta-analysis of the IL-10 -1082 G/A polymorphism showed no association with RA in the study subjects, or in European or Asian subjects. However, meta-analysis of the -1082 G allele in 4 studies in Hardy-Weinberg equilibrium showed a significant association with RA (OR=1.217, 95% CI=1.027-1.442, P=0.0236). In contrast, meta-analysis of the C allele, the CC genotype, and of the CC versus the AA genotype of the IL-10 -592 C/A polymorphism showed significant associations with RA. The overall ORs of the associations between the C allele and RA were 0.684 and 0.758 (95% CI=0.494-0.946, P=0.022; 95% CI=0.475-1.210, P=0.045) in all study subjects and Asians. Meta-analysis of the CC+CT versus TT genotype and of the CC versus TT genotype of the IL-10 -892 C/T polymorphism revealed significant associations with RA. The overall OR of the association between the C allele carrier and RA was 0.552 (95% CI=0.375-0.812, P=0.003). No association was found between the IL10.R2 alleles and RA. This meta-analysis suggests that the IL-10 -592 C/A polymorphism confers susceptibility to RA in Asians and that the IL-10 -1082 G/A and -892 C/T polymorphisms are associated with RA susceptibility. These findings suggest the IL-10 genes confer susceptibility to RA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.