ArticleClinical orthopaedics and related research2011
Evaluation of two sources of calcium sulfate for a local drug delivery system: a pilot study.
Article in Clinical orthopaedics and related research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Staged Treatment of Posttraumatic Tibial Osteomyelitis with Rib Graft and Serratus Anterior Muscle Autografts-Case Report.Journal of personalized medicine · 2023Article
- Elution profiles of metronidazole from calcium sulfate beads.Journal of veterinary science · 2023Article
- Injectable Synthetic Beta-Tricalcium Phosphate/Calcium Sulfate (GeneX) for the Management of Contained Defects Following Curettage of Benign Bone Tumours.Current oncology (Toronto, Ont.) · 2023Article
- Analysis of risk factors for serous exudation of biodegradable material calcium sulfate in the treatment of fracture-related infections.Frontiers in bioengineering and biotechnology · 2023Article
- Can Amoxicillin and Clavulanic Acid Impregnated Plaster of Paris Beads Serve as an Effective Alternative to Systemic Antibiotics for Third Molar Surgeries? A Split Mouth Randomized Clinical Trial.Journal of maxillofacial and oral surgery · 2022Article
- Identifying alternative antibiotics that elute from calcium sulfate beads for treatment of orthopedic infections.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022Article
- Elution Kinetics from Antibiotic-Loaded Calcium Sulfate Beads, Antibiotic-Loaded Polymethacrylate Spacers, and a Powdered Antibiotic Bolus for Surgical Site Infections in a Novel In Vitro Draining Knee Model.Antibiotics (Basel, Switzerland) · 2021Article
- Evaluation of comparative soft tissue response to bone void fillers with antibiotics in a rabbit intramuscular model.Journal of biomaterials applications · 2019Article
- The influence of a calcium sulphate bone void filler on the third-body damage and polyethylene wear of total knee arthroplasty.Bone & joint research · 2019Article
- Careful interpretation of the wound status is needed with use of antibiotic impregnated biodegradable synthetic pure calcium sulfate beads: Series of 39 cases.Journal of bone and joint infection · 2018Article
- Influence of third-body particles originating from bone void fillers on the wear of ultra-high-molecular-weight polyethylene.Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine · 2016Article
- Local release of antibiotics for surgical site infection management using high-purity calcium sulfate: an in vitro elution study.Surgical infections · 2015Article
- Development of an injectable bioactive bone filler cement with hydrogen orthophosphate incorporated calcium sulfate.Journal of materials science. Materials in medicine · 2015Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLocal drug delivery has substantial potential to prevent infections compared with systemic delivery. Although calcium sulfate (CaSO(4)) has been studied for local drug delivery and two types are commercially available, it is unknown whether they differentially release antibiotics. QUESTIONS/PURPOSES: We determined the differences between two sources of CaSO(4) and the K(2)SO(4) catalyst's presence on the degradation, daptomycin elution, and activity against Staphylococcus aureus.
methodsWe formed pellets from synthetic and naturally sourced (from gypsum) CaSO(4) and loaded with 5% daptomycin and 3% or 0% K(2)SO(4). We used in vitro experiments to determine the daptomycin concentration and degradation profiles over 10 days. Turbidity assays were used to evaluate the activity of the daptomycin eluates against S. aureus.
resultsAll pellets exhibited a bolus release with the highest daptomycin concentration on Day 1 with the sourced CaSO(4) pellets. The synthetic CaSO(4) pellets with 3% K(2)SO(4) exhibited a slower drug release compared with the synthetic CaSO(4) pellets with 0% K(2)SO(4), which degraded and eluted daptomycin too quickly to inhibit S. aureus. Turbidity assays demonstrated that all CaSO(4) pellets inhibit S. aureus for expected lengths of time.
conclusionsOur preliminary in vitro data suggest differences in the degradation, elution, and activity properties between sourced and synthetic CaSO(4) pellets. The addition of K(2)SO(4) appeared beneficial when using synthetic CaSO(4). Synthetic CaSO(4) may be effective when slow degradation and longer elution times are needed. CLINICAL RELEVANCE: Local delivery of eluted daptomycin can be tailored through material selection and K(2)SO(4) addition.
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