ArticlePloS one2011
In vivo analysis of inhibitory synaptic inputs and rebounds in deep cerebellar nuclear neurons.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed, 119 citations in OpenAlex.
- Perineuronal nets in cerebellar nuclei neurons orchestrate social behaviour via regulation of neuronal activity in circuits innervated by the cerebellum.Translational psychiatry · 2026Article
- Cerebellar contributions to dystonia: unraveling the role of Purkinje cells and cerebellar nuclei.Dystonia (Lausanne, Switzerland) · 2025Article
- Transsynaptic modulation of cerebellar nuclear cells: theta AC-burst stimulation.Journal of neural engineering · 2024Article
- The Effect of Nucleo-Olivary Stimulation on Climbing Fiber EPSPs in Purkinje Cells.Cerebellum (London, England) · 2024Article
- Cerebellum Lecture: the Cerebellar Nuclei-Core of the Cerebellum.Cerebellum (London, England) · 2024Review
- Complex spikes perturb movements and reveal the sensorimotor map of Purkinje cells.Current biology : CB · 2023Article
- Another Way to Confuse Motor Control: Manual Technique Supposed to Shorten Muscle Spindles Reduces the Muscular Holding Stability in the Sense of Adaptive Force in Male Soccer Players.Brain sciences · 2023Article
- How to Confuse Motor Control: Passive Muscle Shortening after Contraction in Lengthened Position Reduces the Muscular Holding Stability in the Sense of Adaptive Force.Life (Basel, Switzerland) · 2023Article
- Neuronal activity patterns in microcircuits of the cerebellar cortical C3 zone during reaching.The Journal of physiology · 2022Article
- Synchronous spiking of cerebellar Purkinje cells during control of movements.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Case report: Individualized pulsed electromagnetic field therapy in a Long COVID patient using the Adaptive Force as biomarker.Frontiers in medicine · 2022Article
- Is the inferior olive central to essential tremor? Yes.International review of neurobiology · 2022Article
- Disgusting odours affect the characteristics of the Adaptive Force in contrast to neutral and pleasant odours.Scientific reports · 2021Article
- Article
- Gating by Functionally Indivisible Cerebellar Circuits: a Hypothesis.Cerebellum (London, England) · 2021Article
- Increased Purkinje Cell Complex Spike and Deep Cerebellar Nucleus Synchrony as a Potential Basis for Syndromic Essential Tremor. A Review and Synthesis of the Literature.Cerebellum (London, England) · 2021Review
- Modulatory Effects of Monoamines and Perineuronal Nets on Output of Cerebellar Purkinje Cells.Frontiers in neural circuits · 2021Review
- A Non-spiking Neuron Model With Dynamic Leak to Avoid Instability in Recurrent Networks.Frontiers in computational neuroscience · 2021Article
- Article
- Population coding in the cerebellum: a machine learning perspective.Journal of neurophysiology · 2020Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Neuronal function depends on the properties of the synaptic inputs the neuron receive and on its intrinsic responsive properties. However, the conditions for synaptic integration and activation of intrinsic responses may to a large extent depend on the level of background synaptic input. In this respect, the deep cerebellar nuclear (DCN) neurons are of particular interest: they feature a massive background synaptic input and an intrinsic, postinhibitory rebound depolarization with profound effects on the synaptic integration. Using in vivo whole cell patch clamp recordings from DCN cells in the cat, we find that the background of Purkinje cell input provides a tonic inhibitory synaptic noise in the DCN cell. Under these conditions, individual Purkinje cells appear to have a near negligible influence on the DCN cell and clear-cut rebounds are difficult to induce. Peripheral input that drives the simple spike output of the afferent PCs to the DCN cell generates a relatively strong DCN cell inhibition, but do not induce rebounds. In contrast, synchronized climbing fiber activation, which leads to a synchronized input from a large number of Purkinje cells, can induce profound rebound responses. In light of what is known about climbing fiber activation under behaviour, the present findings suggest that DCN cell rebound responses may be an unusual event. Our results also suggest that cortical modulation of DCN cell output require a substantial co-modulation of a large proportion of the PCs that innervate the cell, which is a possible rationale for the existence of the cerebellar microcomplex.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.