ArticlePloS one2011
A role for the immediate early gene product c-fos in imprinting T cells with short-term memory for signal summation.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Gliadin-specific CD4Science advances · 2026Article
- A transcriptional patient map of systemic lupus erythematosus reveals disease-related multicellular immune programs conserved between blood and kidney.bioRxiv : the preprint server for biology · 2026Article
- The universal role of adaptive transcription in health and disease.The FEBS journal · 2025Review
- Single-cell RNA-seq reveals a microenvironment and an exhaustion state of T/NK cells in acute myeloid leukemia.Cancer science · 2023Article
- Light-inducible T cell engagers trigger, tune, and shape the activation of primary T cells.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Integration of intermittent calcium signals in T cells revealed by temporally patterned optogenetics.iScience · 2023Article
- Review
- Hierarchy of signaling thresholds downstream of the T cell receptor and the Tec kinase ITK.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Quantifying persistence in the T-cell signaling network using an optically controllable antigen receptor.Molecular systems biology · 2021Article
- Expression and Functional Characterization ofGenes · 2021Article
- Single-Cell RNA-Seq Analysis Uncovers Distinct Functional Human NKT Cell Sub-Populations in Peripheral Blood.Frontiers in cell and developmental biology · 2020Article
- Initial Viral Inoculum Determines Kinapse-and Synapse-Like T Cell Motility in Reactive Lymph Nodes.Frontiers in immunology · 2019Article
- Unique properties of TCR-activated p38 are necessary for NFAT-dependent T-cell activation.PLoS biology · 2018Article
- IL-2 Modulates the TCR Signaling Threshold for CD8 but Not CD4 T Cell Proliferation on a Single-Cell Level.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- T follicular helper cells in space-time.Nature reviews. Immunology · 2016Review
- A virtual lymph node model to dissect the requirements for T-cell activation by synapses and kinapses.Immunology and cell biology · 2016Article
- T Cell Motility as Modulator of Interactions with Dendritic Cells.Frontiers in immunology · 2015Review
- The Timing of T Cell Priming and Cycling.Frontiers in immunology · 2015Review
- Quantitative and temporal requirements revealed for Zap70 catalytic activity during T cell development.Nature immunology · 2014Article
- Concomitant evaluation of PMA+ionomycin-induced kinase phosphorylation and cytokine production in T cell subsets by flow cytometry.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2014Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
T cells often make sequential contacts with multiple DCs in the lymph nodes and are likely to be equipped with mechanisms that allow them to sum up the successive signals received. We found that a period of stimulation as short as two hours could imprint on a T cell a "biochemical memory" of that activation signal that persisted for several hours. This was evidenced by more rapid induction of activation markers and earlier commitment to proliferation upon subsequent stimulation, even when that secondary stimulation occurred hours later. Upregulation of the immediate early gene product c-fos, a component of the AP-1 transcription factor, was maximal by 1-2 hours of stimulation, and protein levels remained elevated for several hours after stimulus withdrawal. Moreover, phosphorylated forms of c-fos that are stable and transcriptionally active persisted for a least a day. Upon brief antigenic stimulation in vivo, we also observed a rapid upregulation of c-fos that could be boosted by subsequent stimulation. Accumulation of phosphorylated c-fos may therefore serve as a biochemical fingerprint of previous suboptimal stimulation, leaving the T cell poised to rapidly resume its activation program upon its next encounter with an antigen-bearing DC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.