ArticlePloS one2011
Inactivation of the DNA repair genes mutS, mutL or the anti-recombination gene mutS2 leads to activation of vitamin B1 biosynthesis genes.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Thiamine (Vitamin B1)-An Essential Health Regulator.Nutrients · 2025Review
- Putrescine Supplementation Limits the Expansion of pks+ Escherichia coli and Tumor Development in the Colon.Cancer research communications · 2024Article
- Molecular basis of the phenotypic variants arising from aMicrobial genomics · 2023Article
- Expansion of the SOS regulon of Vibrio cholerae through extensive transcriptome analysis and experimental validation.BMC genomics · 2018Article
- Molecular basis for the functions of a bacterial MutS2 in DNA repair and recombination.DNA repair · 2017Article
- Roles of Mn-catalase and a possible heme peroxidase homologue in protection from oxidative stress in Thermus thermophilus.Extremophiles : life under extreme conditions · 2015Article
- Multiple mutations and increased RNA expression in tetracycline-resistant Streptococcus pneumoniae as determined by genome-wide DNA and mRNA sequencing.The Journal of antimicrobial chemotherapy · 2015Article
- Archetypal analysis of diverse Pseudomonas aeruginosa transcriptomes reveals adaptation in cystic fibrosis airways.BMC bioinformatics · 2013Article
- Enhancing E. coli tolerance towards oxidative stress via engineering its global regulator cAMP receptor protein (CRP).PloS one · 2012Article
- Characterization of multi-functional properties and conformational analysis of MutS2 from Thermotoga maritima MSB8.PloS one · 2012Article
- In vivo, in vitro, and x-ray crystallographic analyses suggest the involvement of an uncharacterized triose-phosphate isomerase (TIM) barrel protein in protection against oxidative stress.The Journal of biological chemistry · 2011Article
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Authors and funding
5 authors.
Funding
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Abstract
Oxidative stress generates harmful reactive oxygen species (ROS) that attack biomolecules including DNA. In living cells, there are several mechanisms for detoxifying ROS and repairing oxidatively-damaged DNA. In this study, transcriptomic analyses clarified that disruption of DNA repair genes mutS and mutL, or the anti-recombination gene mutS2, in Thermus thermophilus HB8, induces the biosynthesis pathway for vitamin B(1), which can serve as an ROS scavenger. In addition, disruption of mutS, mutL, or mutS2 resulted in an increased rate of oxidative stress-induced mutagenesis. Co-immunoprecipitation and pull-down experiments revealed previously-unknown interactions of MutS2 with MutS and MutL, indicating that these proteins cooperatively participate in the repair of oxidatively damaged DNA. These results suggested that bacterial cells sense the accumulation of oxidative DNA damage or absence of DNA repair activity, and signal the information to the transcriptional regulation machinery for an ROS-detoxifying system.
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