ArticleTopics in current genetics2007
Biochemistry of eukaryotic homologous recombination.
Article in Topics in current genetics, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 90 citations in OpenAlex.
- Structural evidence for an inThe Journal of biological chemistry · 2019Article
- The recombinase Rad51 plays a key role in events of genetic exchange in Trypanosoma cruzi.Scientific reports · 2018Article
- Reconstituted System for the Examination of Repair DNA Synthesis in Homologous Recombination.Methods in enzymology · 2017Article
- Nonsense-mediated decay regulates key components of homologous recombination.Nucleic acids research · 2016Article
- Error-Prone Repair of DNA Double-Strand Breaks.Journal of cellular physiology · 2016Review
- Loss of heterozygosity for chromosomal regions 15q14-21.1, 17q21.31, and 13q12.3-13.1 and its relevance for prostate cancer.Medical oncology (Northwood, London, England) · 2015Article
- Regulation of recombination and genomic maintenance.Cold Spring Harbor perspectives in biology · 2015Review
- Promotion of presynaptic filament assembly by the ensemble of S. cerevisiae Rad51 paralogues with Rad52.Nature communications · 2015Article
- Roles of Rad51 paralogs for promoting homologous recombination in Leishmania infantum.Nucleic acids research · 2015Article
- Top3-Rmi1 dissolve Rad51-mediated D loops by a topoisomerase-based mechanism.Molecular cell · 2015Article
- Polymorphism within the distal RAD51 gene promoter is associated with colorectal cancer in a Polish population.International journal of clinical and experimental pathology · 2015Article
- Visualization and quantification of nascent RAD51 filament formation at single-monomer resolution.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Mismatch repair protein hMSH2-hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediate.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A conserved sequence extending motif III of the motor domain in the Snf2-family DNA translocase Rad54 is critical for ATPase activity.PloS one · 2013Article
- From yeast to mammals: recent advances in genetic control of homologous recombination.DNA repair · 2012Review
- Article
- Single-molecule views of protein movement on single-stranded DNA.Annual review of biophysics · 2012Review
- Functions of the Snf2/Swi2 family Rad54 motor protein in homologous recombination.Biochimica et biophysica acta · 2011Review
- Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes.Chromosoma · 2011Review
- Who's who in human recombination: BRCA2 and RAD52.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
Abstract
The biochemistry of eukaryotic homologous recombination caught fire with the discovery that Rad51 is the eukaryotic homolog of the bacterial RecA and T4 UvsX proteins; and this field is still hot. The core reaction of homologous recombination, homology search and DNA strand invasion, along with the proteins catalyzing it, are conserved throughout evolution in principle. However, the increased complexity of eukaryotic genomes and the diversity of eukaryotic cell biology pose additional challenges to the recombination machinery. It is not surprising that this increase in complexity coincided with the evolution of new recombination proteins and novel support pathways, as well as changes in the properties of those eukaryotic recombination proteins that are evidently conserved in evolution. In humans, defects in homologous recombination lead to increased cancer predisposition, underlining the importance of this pathway for genomic stability and tumor suppression. This review will focus on the mechanisms of homologous recombination in eukaryotes as elucidated by the biochemical analysis of yeast and human proteins.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.