ArticleImmunology1990
Stimulation of human rheumatoid synovial cells by non-lethal complement membrane attack.
Article in Immunology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Who cites it
16 citing papers in PubMed, 38 citations in OpenAlex.
- Therapeutic Efficacy of aFrontiers in microbiology · 2020Article
- Complement Attack against Aspergillus and Corresponding Evasion Mechanisms.Interdisciplinary perspectives on infectious diseases · 2012Article
- Complement and periodontitis.Biochemical pharmacology · 2010Review
- Statin-induced expression of CD59 on vascular endothelium in hypoxia: a potential mechanism for the anti-inflammatory actions of statins in rheumatoid arthritis.Arthritis research & therapy · 2006Article
- Modulation of leukocyte recruitment and IL-8 expression by the membrane attack complex of complement (C5b-9) in a rabbit model of antigen-induced arthritis.Inflammation · 2002Article
- Urinary Tract Infection in Pregnant Women: Old Dogmas and Current Concepts Regarding Pathogenesis.Current infectious disease reports · 2002Article
- Comparison of the suppressive effects of soluble CR1 and C5a receptor antagonist in acute arthritis induced in rats by blocking of CD59.Clinical and experimental immunology · 2000Article
- Complement in acute and chronic arthritides: assessment of C3c, C9, and protectin (CD59) in synovial membrane.Annals of the rheumatic diseases · 1996Article
- Adhesion molecule expression and complement activation in vessel walls in synovial tissue from patients with chronic inflammatory joint disease.Clinical rheumatology · 1996Article
- The membrane attack complex of complement induces interleukin-8 and monocyte chemoattractant protein-1 secretion from human umbilical vein endothelial cells.The American journal of pathology · 1996Article
- Amelioration of lupus-like autoimmune disease in NZB/WF1 mice after treatment with a blocking monoclonal antibody specific for complement component C5.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Anti-C5 monoclonal antibody therapy prevents collagen-induced arthritis and ameliorates established disease.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Terminal complement complexes and C1/C1 inhibitor complexes in rheumatoid arthritis and other arthritic conditions.Clinical and experimental immunology · 1991Article
- The complement-inhibiting protein, protectin (CD59 antigen), is present and functionally active on glomerular epithelial cells.Clinical and experimental immunology · 1991Article
- Human rheumatoid synovial cell stimulation by the membrane attack complex and other pore-forming toxins in vitro: the role of calcium in cell activation.Immunology · 1990Article
- Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The effects of non-lethal complement attack on cultured human rheumatoid synovial cells have been investigated by measuring a variety of parameters. Within 3-4 min of initiating non-lethal complement membrane attack there was a rise in reactive oxygen metabolite release from cultured synovial cells, which slowly returned to basal levels over a period of 45 min. The response was dependent on the formation of the complete C5b-9 complex. Prostaglandin E2 was also released during non-lethal attack in a biphasic manner, an early phase of release occurring within the first hour and a second, larger phase commencing at 4 hr and rising to levels of over 1000 ng/10(6) cells at 24 hr, compared to control levels at this time of less than 100 ng/10(6) cells. This response was dependent on the formation of the C5b-8 complex but did not require C9. Removal of extracellular calcium reduced release of prostaglandin E2 to background levels, and inclusion of an inhibitor of protein synthesis abolished the second phase of release but not the first phase. Non-lethal attack caused release of small amounts of leukotriene B4 but no detectable release of tumour necrosis factor.
Indexed as
Identifiers
2155179PMC1385595W98575697What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.