ArticleJournal of immunology (Baltimore, Md. : 1950)2011
IL-17A-dependent CD4+CD25+ regulatory T cells promote immune privilege of corneal allografts.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 56 citations in OpenAlex.
- Role of DZ2002 in reducing corneal graft rejection in rats by influencing Th17 activation via inhibition of the PI3K/AKT pathway and downregulation of TRAF1.Open life sciences · 2025Article
- The Host-Pathogen Interplay: A Tale of Two Stories within the Cornea and Posterior Segment.Microorganisms · 2023Review
- Role of Immune Cell Diversity and Heterogeneity in Corneal Graft Survival: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2021Review
- The Defect in Regulatory T Cells in Psoriasis and Therapeutic Approaches.Journal of clinical medicine · 2021Review
- Review
- Basic fibroblast growth factor and agarose gel promote the ability of immune privilege of allogeneic cartilage transplantation in rats.Journal of orthopaedic translation · 2020Article
- Corneal Nerve Ablation Abolishes Ocular Immune Privilege by Downregulating CD103 on T Regulatory Cells.Investigative ophthalmology & visual science · 2020Article
- Regulatory T cells promote corneal endothelial cell survival following transplantation via interleukin-10.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020Article
- The Eye Sees Eye to Eye With the Immune System: The 2019 Proctor Lecture.Investigative ophthalmology & visual science · 2019Article
- CD55 Is Essential for CD103The American journal of pathology · 2019Article
- Local Delivery of Regulatory T Cells Promotes Corneal Allograft Survival.Transplantation · 2019Article
- Tocilizumab promotes corneal allograft survival in rats by modulating Treg-Th17 balance.International journal of ophthalmology · 2019Article
- Engineering of Human Corneal Endothelial CellsInternational journal of medical sciences · 2019Review
- Regulatory T cell modulation of cytokine and cellular networks in corneal graft rejection.Current ophthalmology reports · 2018Article
- UV light crosslinking regresses mature corneal blood and lymphatic vessels and promotes subsequent high-risk corneal transplant survival.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018Article
- Induction of Contrasuppressor Cells and Loss of Immune Privilege Produced by Corneal Nerve Ablation.Investigative ophthalmology & visual science · 2018Article
- Therapeutic approaches for induction of tolerance and immune quiescence in corneal allotransplantation.Cellular and molecular life sciences : CMLS · 2018Review
- When Clarity Is Crucial: Regulating Ocular Surface Immunity.Trends in immunology · 2018Review
- Review: The function of regulatory T cells at the ocular surface.The ocular surface · 2017Review
- Comparative Analyses of Immunosuppressive Characteristics of Bone-Marrow, Wharton's Jelly, and Adipose Tissue-Derived Human Mesenchymal Stem Cells.Turkish journal of haematology : official journal of Turkish Society of Haematology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
IL-17A is a proinflammatory cytokine that has received attention for its role in the pathogenesis of several autoimmune diseases. IL-17A has also been implicated in cardiac and renal allograft rejection. Accordingly, we hypothesized that depletion of IL-17A would enhance corneal allograft survival. Instead, our results demonstrate that blocking IL-17A in a mouse model of keratoplasty accelerated the tempo and increased the incidence of allograft rejection from 50 to 90%. We describe a novel mechanism by which CD4(+)CD25(+) regulatory T cells (Tregs) respond to IL-17A and enhance corneal allograft survival. Our findings suggest the following: 1) IL-17A is necessary for ocular immune privilege; 2) IL-17A is not required for the induction of anterior chamber-associated immune deviation; 3) Tregs require IL-17A to mediate a contact-dependent suppression; 4) corneal allograft Tregs suppress the efferent arm of the immune response and are Ag specific; 5) Tregs are not required for corneal allograft survival beyond day 30; and 6) corneal allograft-induced Treg-mediated suppression is transient. Our findings identify IL-17A as a cytokine essential for the maintenance of corneal immune privilege and establish a new paradigm whereby interplay between IL-17A and CD4(+)CD25(+) Tregs is necessary for survival of corneal allografts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.