ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Development of a preclinical model of ischemic cardiomyopathy in swine.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Developing and evaluating a chronic ischemic cardiomyopathy in swine model by rest and stress CMR.The international journal of cardiovascular imaging · 2024Article
- Echocardiographic Left Ventricular Mass Estimation: Two-Dimensional Area-Length Method is Superior to M-Mode Linear Method in Swine Models of Cardiac Diseases.Journal of cardiovascular translational research · 2020Article
- Experimental models of cardiac physiology and pathology.Heart failure reviews · 2019Review
- Human Cardiac Gene Therapy.Circulation research · 2018Review
- Left Ventricular Unloading Using an Impella CP Improves Coronary Flow and Infarct Zone Perfusion in Ischemic Heart Failure.Journal of the American Heart Association · 2018Article
- Swine (Sus scrofa) as a Model of Postinfarction Mitral Regurgitation and Techniques to Accommodate Its Effects during Surgical Repair.Comparative medicine · 2016Article
- Creation of clinically relevant model of chronic heart failure: Application of multi-modality imaging to define physiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Cardiac remodeling in a new pig model of chronic heart failure: Assessment of left ventricular functional, metabolic, and structural changes using PET, CT, and echocardiography.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2015Article
- Repetitive myocardial ischemia promotes coronary growth in the adult mammalian heart.Journal of the American Heart Association · 2013Article
- The role of large animal studies in cardiac regenerative therapy concise review of translational stem cell research.Korean circulation journal · 2013Review
- Temporal changes of strain parameters in the progress of chronic ischemia: with comparison to transmural infarction.The international journal of cardiovascular imaging · 2012Article
- Myocardial infarction and intramyocardial injection models in swine.Nature protocols · 2012Article
- Cardiac gene therapy in large animals: bridge from bench to bedside.Gene therapy · 2012Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
A number of promising therapies for ischemic cardiomyopathy are emerging, and the role of translational research in testing the efficacy and safety of these agents in relevant clinical models has become important. The goal of this study was to develop a chronic model of ischemic cardiomyopathy in a large animal model. In this study, 40 consecutive pigs were initially enrolled. To induce progressive stenosis, a plastic occluder with a fixed diameter of 1.0 mm fitted with an 18-gauge copper wire was placed around the proximal left anterior descending (LAD) coronary artery. Coronary angiography, hemodynamic measurements, and echocardiography were performed at 2 wk and 1, 2, and 3 mo. Overall mortality was 26% at 3 mo, and up to 80% of the pigs showed total occlusion of LAD at 1 mo. A significant depression of peak LV pressure rate of rise (+dP/dt(max)) was observed in the animals showing total artery occlusion throughout the study. Left ventricular ejection fraction was also impaired, and the left ventricular volumes tended to be larger in the pigs with occlusion. Approximately 10% of scar tissue was found in the LAD occluded pigs, whereas the coronary flow pattern in the rest of the area took the pattern of hibernating myocardium. At the same time, histological and protein analysis established the presence of fibrosis and ongoing apoptosis in the ischemic area. In this model, the timing and incidence of total occlusion and low mortality offer significant advantages over other ischemic cardiomyopathy models in conducting preclinical studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.