Trial reportSocial cognitive and affective neuroscience2012
The association between financial hardship and amygdala and hippocampal volumes: results from the PATH through life project.
Trial report in Social cognitive and affective neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of associations between childhood adversity and hippocampus and amygdala volume in non-clinical and general population samples.NeuroImage. Clinical · 2017Pooled it
- Sociodemographic disparities in corticolimbic structures.PloS one · 2019Trial
- Examination of poverty trajectories and brain volume as predictors of adolescent depression.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- Contribution of Life-Course Socioeconomic Position to Later-Life Brain Volumes in US Hispanic/Latino Adults.Neurology · 2026Article
- Persistent financial adversity and cognitive aging: a life course investigation.Innovation in aging · 2026Article
- Large-Scale Brain Networks Track Gasoline Price Shifts.bioRxiv : the preprint server for biology · 2025Article
- Family Income Is Associated With Regional Brain Glucose Metabolism in Middle-Aged Males.The European journal of neuroscience · 2025Article
- Health insurance coverage moderates the relationship between metabolic syndrome and baseline memory outcomes in Latino older adults.The Clinical neuropsychologist · 2025Article
- Grief and Economic Stressors by Sex, Gender, and Education: Associations With Alzheimer Disease-Related Outcomes.Neurology · 2025Article
- Testing a syndemics perspective on the effects of multiple adversities on depression and anxiety symptoms in a representative population sample.Social psychiatry and psychiatric epidemiology · 2024Article
- The impact of psychosocial adversity on brain and behaviour: an overview of existing knowledge and directions for future research.Molecular psychiatry · 2024Review
- Reconsidering the nature of threat in infancy: Integrating animal and human studies on neurobiological effects of infant stress.Neuroscience and biobehavioral reviews · 2024Review
- Multiple group membership and executive function in a socioeconomically diverse sample.Scientific reports · 2024Article
- The Effects of Midlife Acute and Chronic Stressors on Black-White Differences in Cognitive Decline.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Article
- Article
- Depression among medical students in Tunisia: Prevalence and associated factors.World journal of psychiatry · 2023Article
- Low neighborhood deprivation buffers against hippocampal neurodegeneration, white matter hyperintensities, and poorer cognition.GeroScience · 2023Article
- The times they are a-changin': a proposal on how brain flexibility goes beyond the obvious to include the concepts of "upward" and "downward" to neuroplasticity.Molecular psychiatry · 2023Review
- Financial Hardship, Depression, and Self-Esteem: Temporal Analysis Using a Korean Panel Study.Psychiatry investigation · 2023Article
- Introduction to the Special Issue on the Exposome-Understanding Environmental Impacts on Brain Development and Risk for Psychopathology.Biological psychiatry global open science · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined whether middle-aged adults exposed to poverty in childhood or current financial hardship have detectable brain differences from those who have not experienced such adversity. Structural magnetic resonance imaging (MRI) was conducted as one aspect of the Personality and Total Health (PATH) through life study: a large longitudinal community survey measuring the health and well-being of three cohorts from south-eastern Australia. This analysis considers data from 431 middle-aged adults in the aged 44-48 years at the time of the interview. Volumetric segmentation was performed with the Freesurfer image analysis suite. Data on socio-demographic circumstances, mental health and cognitive performance were collected through the survey interview. Results showed that, after controlling for well-established risk factors for atrophy, adults who reported financial hardship had smaller left and right hippocampal and amygdalar volumes than those who did not report hardship. In contrast, there was no reliable association between hardship and intra-cranial volume or between childhood poverty and any of the volumetric measures. Financial hardship may be considered a potent stressor and the observed results are consistent with the view that hardship influences hippocampal and amygdalar volumes through hypothalamic-pituitary-adrenal axis function and other stress-related pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.