Evidence map›Paper›PMID 21551146›Full record

ArticleBioinformatics (Oxford, England)2011

Sim4db and Leaff: utilities for fast batch spliced alignment and sequence indexing.

Brian Walenz, Liliana Florea

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Genomic variation across distribution of Micro-Tom, a model cultivar of tomato (Solanum lycopersicum).DNA research : an international journal for rapid publication of reports on genes and genomes · 2024
    Article
  2. Detection ofFrontiers in molecular biosciences · 2021
    Article
  3. Genes & development · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Brian WalenzThe J. Craig Venter Institute, Rockville, MD 20850, USA.
Liliana Florea

Funding

COMPUTATIONAL MODELING OF GENES AND GENE STRUCTURER01LM006845 · NLM · UNIV OF MARYLAND, COLLEGE PARK · PI SALZBERG, STEVEN L. · 1999 to 2010
$5.9M
NLM NIH HHS R01-LM006845
6 · The paper itself

Abstract

unlabelledThe large number of genomes that will be sequenced will need to be annotated with genes and other functional features. Aligning gene sequences from a related species to the target genome is an economical and highly reliable method to identify genes; unfortunately, existing tools have been lacking in sensitivity and speed. A program we reported, sim4cc, was shown to be highly accurate but is limited to comparing one cDNA with one genomic sequence. We present here an optimization of the tool, implemented in the packages sim4db and leaff. The new tool performs batch alignments of cDNA and genomic sequences in a fraction of the time required by its predecessor, and thus is very well suited for genome-wide analyses. AVAILABILITY: Sim4db and leaff are written in C, C++ and Perl for Linux and other Unix platforms. Source code is distributed free of charge from http://sourceforge.net/projects/kmer/. CONTACT: florea@umiacs.umd.edu

Indexed as

SoftwareAnimalsBase SequenceBiological EvolutionDNA, ComplementaryGenomeHumansRNA SplicingSequence AlignmentVertebratesDNA, Complementary

Identifiers

PMID21551146
PMCPMC3117389

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.