ArticleMolecular biology of the cell2011
Focal adhesion kinase protein regulates Wnt3a gene expression to control cell fate specification in the developing neural plate.
Article in Molecular biology of the cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Tissue flow acts as a guidance cue for immune cell polarization and directional migration.Nature cell biology · 2026Article
- Analysis of the potential regulatory mechanism of PIEZO1 in Alzheimer's disease based on RNA sequencing.IBRO neuroscience reports · 2025Article
- Focal Adhesion Kinase Variants May Contribute to Risk of Human Myelomeningocele.medRxiv : the preprint server for health sciences · 2025Article
- Cancer-Associated Adipocytes in Breast Cancer: Causes and Consequences.International journal of molecular sciences · 2021Review
- The Crosstalk between FAK and Wnt Signaling Pathways in Cancer and Its Therapeutic Implication.International journal of molecular sciences · 2020Review
- Modeling Bainbridge-Ropers Syndrome inFrontiers in physiology · 2020Article
- New roles for Wnt and BMP signaling in neural anteroposterior patterning.EMBO reports · 2019Article
- GLIS3 Transcriptionally Activates WNT Genes to Promote Differentiation of Human Embryonic Stem Cells into Posterior Neural Progenitors.Stem cells (Dayton, Ohio) · 2019Article
- Article
- Addressing the Functional Determinants of FAK during Ciliogenesis in Multiciliated Cells.The Journal of biological chemistry · 2017Article
- FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation by Enhancing Wnt Signaling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Article
- Wnt3a: functions and implications in cancer.Chinese journal of cancer · 2015Review
- Down-regulation of ALDH1A3, CD44 or MDR1 sensitizes resistant cancer cells to FAK autophosphorylation inhibitor Y15.Journal of cancer research and clinical oncology · 2015Article
- Insulin-like factor regulates neural induction through an IGF1 receptor-independent mechanism.Scientific reports · 2015Article
- FAK is required for tension-dependent organization of collective cell movements in Xenopus mesendoderm.Developmental biology · 2014Article
- RhoA controls Wnt upregulation on microstructured titanium surfaces.BioMed research international · 2014Article
- Targeting FAK in human cancer: from finding to first clinical trials.Frontiers in bioscience (Landmark edition) · 2014Review
- p190-B RhoGAP regulates the functional composition of the mesenchymal microenvironment.Leukemia · 2013Article
- FAK and HAS inhibition synergistically decrease colon cancer cell viability and affect expression of critical genes.Anti-cancer agents in medicinal chemistry · 2013Article
- Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated.The Journal of biological chemistry · 2012Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase protein localized to regions called focal adhesions, which are contact points between cells and the extracellular matrix. FAK protein acts as a scaffold to transfer adhesion-dependent and growth factor signals into the cell. Increased FAK expression is linked to aggressive metastatic and invasive tumors. However, little is known about its normal embryonic function. FAK protein knockdown during early Xenopus laevis development anteriorizes the embryo. Morphant embryos express increased levels of anterior neural markers, with reciprocally reduced posterior neural marker expression. Posterior neural plate folding and convergence-extension is also inhibited. This anteriorized phenotype resembles that of embryos knocked down zygotically for canonical Wnt signaling. FAK and Wnt3a genes are both expressed in the neural plate, and Wnt3a expression is FAK dependent. Ectopic Wnt expression rescues this FAK morphant anteriorized phenotype. Wnt3a thus acts downstream of FAK to balance anterior-posterior cell fate specification in the developing neural plate. Wnt3a gene expression is also FAK dependent in human breast cancer cells, suggesting that this FAK-Wnt linkage is highly conserved. This unique observation connects the FAK- and Wnt-signaling pathways, both of which act to promote cancer when aberrantly activated in mammalian cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.