ArticleMechanisms of ageing and development2011
Multiple suppression pathways of canonical Wnt signalling control thymic epithelial senescence.
Article in Mechanisms of ageing and development, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 38 citations in OpenAlex.
- T cell senescence and exhaustion: molecular mechanisms and immune rejuvenation for cancer immunotherapy.Signal transduction and targeted therapy · 2026Review
- HOXC10 Protects from Skin Aging by Targeting the FZD6/Wnt/β-Catenin Signaling Pathway.Research (Washington, D.C.) · 2025Article
- Age-Related Thymic Involution.Advances in experimental medicine and biology · 2025Review
- Cell Culture Models for Translational Research on Thymomas and Thymic Carcinomas: Current Status and Future Perspectives.Cancers · 2024Review
- Non-Mutational Key Features in the Biology of Thymomas.Cancers · 2024Review
- Narrative Review: Glucocorticoids in Alcoholic Hepatitis-Benefits, Side Effects, and Mechanisms.Journal of xenobiotics · 2022Review
- Fine-tuning of β-catenin in mouse thymic epithelial cells is required for postnatal T-cell development.eLife · 2022Article
- WNT4 overexpression and secretion in thymic epithelial tumors drive an autocrine loop in tumor cellsFrontiers in oncology · 2022Article
- Key Factors for Thymic Function and Development.Frontiers in immunology · 2022Review
- Delayed maturation of thymic epithelium in mice with specific deletion of β-catenin gene in FoxN1 positive cells.Histochemistry and cell biology · 2021Article
- Review
- Transgenic Exosomes for Thymus Regeneration.Frontiers in immunology · 2019Article
- Elevated levels of Wnt signaling disrupt thymus morphogenesis and function.Scientific reports · 2017Article
- Detection of Quiescent Radioresistant Epithelial Progenitors in the Adult Thymus.Frontiers in immunology · 2017Article
- PPARgamma Deficiency Counteracts Thymic Senescence.Frontiers in immunology · 2017Article
- MicroRNA-205 Maintains T Cell Development following Stress by Regulating Forkhead Box N1 and Selected Chemokines.The Journal of biological chemistry · 2016Article
- Epigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence.World journal of biological chemistry · 2016Article
- WNT signaling suppression in the senescent human thymus.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
- Thymic epithelial cell development and its dysfunction in human diseases.BioMed research international · 2014Review
- Thymus involution and regeneration: two sides of the same coin?Nature reviews. Immunology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Members of the Wnt family of secreted glyco-lipo-proteins affect intrathymic T-cell development and are abundantly secreted by thymic epithelial cells (TECs) that create the specific microenvironment for thymocytes to develop into mature T-cells. During ageing, Wnt expression declines allowing adipoid involution of the thymic epithelium leading to reduced naïve T-cell output. The protein kinase C (PKC) family of serine-threonine kinases is involved in numerous intracellular biochemical processes, including Wnt signal transduction. In the present study, PKCδ expression is shown to increase with age and to co-localise with Wnt receptors Frizzled (Fz)-4 and -6. It is also demonstrated that connective tissue growth factor (CTGF) is a Wnt-4 target gene and is potentially involved in a negative feed-back loop of Wnt signal regulation. Down-regulation of Wnt-4 expression and activation of multiple repressor pathways suppressing β-catenin dependent signalling in TECs contribute to the initiation of thymic senescence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.