ArticleCurrent biology : CB2011
TRPM channels modulate epileptic-like convulsions via systemic ion homeostasis.
Article in Current biology : CB, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Diverse species of animal models in epilepsy research: Progress and perspectives.Zoological research · 2025Review
- The ketone body β-hydroxybutyrate ameliorates neurodevelopmental deficits in the GABAergic system ofeLife · 2024Article
- Structural and physiological functions ofHeliyon · 2024Review
- Electrocardiogram Changes in the Postictal Phase of Epileptic Seizure: Results from a Prospective Study.Journal of clinical medicine · 2023Article
- Transient Receptor Potential (TRP) Channels in Pain, Neuropsychiatric Disorders, and Epilepsy.International journal of molecular sciences · 2023Review
- Natural Bioactive Products and Alzheimer's Disease Pathology: Lessons fromDiseases (Basel, Switzerland) · 2022Review
- Neuronal transcriptome analyses reveal novel neuropeptide modulators of excitation and inhibition imbalance in C. elegans.PloS one · 2020Article
- Gain-of-function mutations in the UNC-2/CaV2α channel lead to excitation-dominant synaptic transmission ineLife · 2019Article
- GTL-1, a Calcium Activated TRPM Channel, Enhances Nociception.Frontiers in pharmacology · 2019Article
- An Antimicrobial Peptide and Its Neuronal Receptor Regulate Dendrite Degeneration in Aging and Infection.Neuron · 2018Article
- Novel Mutations in Synaptic Transmission Genes Suppress Neuronal Hyperexcitation inG3 (Bethesda, Md.) · 2017Article
- Dynamic changes in murine forebrain miR-211 expression associate with cholinergic imbalances and epileptiform activity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Asynchronous Cholinergic Drive Correlates with Excitation-Inhibition Imbalance via a Neuronal CaCell reports · 2017Article
- The HECT Family Ubiquitin Ligase EEL-1 Regulates Neuronal Function and Development.Cell reports · 2017Article
- Highly efficient optogenetic cell ablation in C. elegans using membrane-targeted miniSOG.Scientific reports · 2016Article
- Article
- A novel nondevelopmental role of the sax-7/L1CAM cell adhesion molecule in synaptic regulation in Caenorhabditis elegans.Genetics · 2015Article
- Novel Alleles of gon-2, a C. elegans Ortholog of Mammalian TRPM6 and TRPM7, Obtained by Genetic Reversion Screens.PloS one · 2015Article
- Using C. elegans to decipher the cellular and molecular mechanisms underlying neurodevelopmental disorders.Molecular neurobiology · 2013Review
- Optogenetic inhibition of synaptic release with chromophore-assisted light inactivation (CALI).Neuron · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Neuronal networks operate over a wide range of activity levels, with both neuronal and nonneuronal cells contributing to the balance of excitation and inhibition. Activity imbalance within neuronal networks underlies many neurological diseases, such as epilepsy. The Caenorhabditis elegans locomotor circuit operates via coordinated activity of cholinergic excitatory and GABAergic inhibitory transmission. We have previously shown that a gain-of-function mutation in a neuronal acetylcholine receptor, acr-2(gf), causes an epileptic-like convulsion behavior. Here we report that the behavioral and physiological effects of acr-2(gf) require the activity of the TRPM channel GTL-2 in nonneuronal tissues. Loss of gtl-2 function does not affect baseline synaptic transmission but can compensate for the excitation-inhibition imbalance caused by acr-2(gf). The compensatory effects of removing gtl-2 are counterbalanced by another TRPM channel, GTL-1, and can be recapitulated by acute treatment with divalent cation chelators, including those specific for Zn(2+). Together, these data reveal an important role for ion homeostasis in the balance of neuronal network activity and a novel function of nonneuronal TRPM channels in the fine-tuning of this network activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.