Evidence map›Paper›PMID 21549324›Full record

ReviewCell stem cell2011

Deadly teamwork: neural cancer stem cells and the tumor microenvironment.

Justin D Lathia, John M Heddleston, Monica Venere, Jeremy N Rich

Abstract readReview
In one paragraph

Review in Cell stem cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 151 papers.

0numbers the graph read from it
0cells of the map it votes in
151citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

151 citing papers in PubMed.

  1. Article
  2. Article
  3. Understanding Glioblastoma Dynamics Using 3D Organoids and Engineered Extracellular Matrix.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Article
  5. Current Understanding of the Exosomes and Their Associated Biomolecules in the Glioblastoma Biology, Clinical Treatment, and Diagnosis.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
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  14. Article
  15. Review
  16. Article
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  20. Review

91 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Justin D LathiaDepartment of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44118, USA. lathiaj@ccf.org
John M Heddleston
Monica Venere
Jeremy N Rich

Funding

Targeting Brain Tumor Stem Cells Through Novel Therapeutic CombinationsR01CA154130 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI RICH, JEREMY N · 2010 to 2014
$1.9M
Stem Cell-Like Glioma Cells in AngiogenesisR01CA129958 · NCI · DUKE UNIVERSITY · PI RICH, JEREMY N · 2008 to 2012
$1.6M
TGFbeta-PTEN Interactions in Glioma Biology & TherapyR01CA116659 · NCI · DUKE UNIVERSITY · PI RICH, JEREMY N · 2006 to 2010
$1.4M
Molecular Mechanisms of SPARC Mediated Glioma InvasionR01NS054276 · NINDS · DUKE UNIVERSITY · PI RICH, JEREMY N · 2006 to 2010
$1.2M
p53, Rb and Ras Pathways in Neural Stem Cell Homeostasis and TransformationF32NS058042 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VENERE, MONICA · 2007 to 2009
$141k
Integrin regulation of brain tumor initiating cellsF32CA142159 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI LATHIA, JUSTIN D. · 2009 to 2011
$98k
NCI NIH HHS F32 CA142159NCI NIH HHS R01 CA116659NCI NIH HHS R01 CA129958NCI NIH HHS R01 CA154130NINDS NIH HHS F32 NS058042NINDS NIH HHS R01 NS054276
6 · The paper itself

Abstract

Neural cancers display cellular hierarchies with self-renewing tumorigenic cancer stem cells (CSCs) at the apex. Instructive cues to maintain CSCs are generated by both intrinsic networks and the niche microenvironment. The CSC-microenvironment relationship is complex, as CSCs can modify their environment and extrinsic forces induce plasticity in the cellular hierarchy.

Indexed as

Cell CommunicationAnimalsCell Transformation, NeoplasticDisease ProgressionGlioblastomaHumansModels, BiologicalNeoplasm MetastasisNeoplastic Stem CellsNervous System NeoplasmsStem Cell NicheTumor Microenvironment

Identifiers

PMID21549324
PMCPMC3494093

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.