ArticleMolecular brain2011
Physiological synaptic signals initiate sequential spikes at soma of cortical pyramidal neurons.
Article in Molecular brain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Biophysical properties of the membrane influence spike initiation dynamics and neuronal excitability: a focus on Kv1 channels in myelinated axons.Proceedings. Biological sciences · 2025Review
- Rapid synaptic and gamma rhythm signature of mouse critical period plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- microRNA-15b contributes to depression-like behavior in mice by affecting synaptic protein levels and function in the nucleus accumbens.The Journal of biological chemistry · 2020Article
- Cell-specific plasticity associated with integrative memory of triple sensory signals in the barrel cortex.Oncotarget · 2018Article
- Activity strengths of cortical glutamatergic and GABAergic neurons are correlated with transgenerational inheritance of learning ability.Oncotarget · 2017Article
- Piriform cortical glutamatergic and GABAergic neurons express coordinated plasticity for whisker-induced odor recall.Oncotarget · 2017Article
- Functional compatibility between Purkinje cell axon branches and their target neurons in the cerebellum.Oncotarget · 2017Article
- Dual face of axonal inhibitory inputs in the modulation of neuronal excitability in cortical pyramidal neurons.Neural regeneration research · 2017Article
- PKC and CaMK-II inhibitions coordinately rescue ischemia-induced GABAergic neuron dysfunction.Oncotarget · 2017Article
- GABAergic neurons in nucleus accumbens are correlated to resilience and vulnerability to chronic stress for major depression.Oncotarget · 2017Article
- Activity-induced spontaneous spikes in GABAergic neurons suppress seizure discharges: an implication of computational modeling.Oncotarget · 2017Article
- Associative Memory Extinction Is Accompanied by Decayed Plasticity at Motor Cortical Neurons and Persistent Plasticity at Sensory Cortical Neurons.Frontiers in cellular neuroscience · 2017Article
- Coordinated Plasticity among Glutamatergic and GABAergic Neurons and Synapses in the Barrel Cortex Is Correlated to Learning Efficiency.Frontiers in cellular neuroscience · 2017Article
- Incoordination among Subcellular Compartments Is Associated with Depression-Like Behavior Induced by Chronic Mild Stress.The international journal of neuropsychopharmacology · 2016Article
- Glucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala.PloS one · 2016Article
- Associations of Unilateral Whisker and Olfactory Signals Induce Synapse Formation and Memory Cell Recruitment in Bilateral Barrel Cortices: Cellular Mechanism for Unilateral Training Toward Bilateral Memory.Frontiers in cellular neuroscience · 2016Article
- Coordinated Plasticity between Barrel Cortical Glutamatergic and GABAergic Neurons during Associative Memory.Neural plasticity · 2016Article
- A portion of inhibitory neurons in human temporal lobe epilepsy are functionally upregulated: an endogenous mechanism for seizure termination.CNS neuroscience & therapeutics · 2015Article
- Acidosis-Induced Dysfunction of Cortical GABAergic Neurons through Astrocyte-Related Excitotoxicity.PloS one · 2015Article
- Protein kinase C is essential for kainate-induced anxiety-related behavior and glutamatergic synapse upregulation in prelimbic cortex.CNS neuroscience & therapeutics · 2014Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neurons in the brain produce sequential spikes as the digital codes whose various patterns manage well-organized cognitions and behaviors. A source for the physiologically integrated synaptic signals to initiate digital spikes remains unknown, which we studied at pyramidal neurons of cortical slices. In dual recordings from the soma vs. axon, the signals recorded in vivo induce somatic spikes with higher capacity, which is associated with lower somatic thresholds and shorter refractory periods mediated by voltage-gated sodium channels. The introduction of these parameters from the soma and axon into NEURON model simulates sequential spikes being somatic in origin. Physiological signals integrated from synaptic inputs primarily trigger the soma to encode neuronal digital spikes.
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