ArticleJournal of the American Chemical Society2011
1H-Detected 13C photo-CIDNP as a sensitivity enhancement tool in solution NMR.
Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Proton signal enhancement of three orders of magnitude in high-field liquid-state NMR.Nature communications · 2026Article
- Chemical exchange saturation transfer NMR: An analytical tool and its applications.Magnetic resonance letters · 2026Review
- Nuclear-Spin Hyperpolarization of Biomolecules by Optically Enhanced NMR at Ultra-High Field.Journal of the Chinese Chemical Society. Zhongguo hua xue hui (Taipei, Taiwan) · 2026Article
- Detection of the Carcinogen Benzo[Analytical chemistry · 2026Article
- Predictions of Steady-State Photo-CIDNP Enhancement by Machine Learning.Journal of the American Chemical Society · 2025Article
- Dynamic nuclear polarization and chemically induced hyperpolarization: Progress, mechanisms, and opportunities.Magnetic resonance letters · 2025Review
- Photo-CIDNP for quantification of micromolar analytes in urine.Communications chemistry · 2025Article
- Bullet-DNP Enables NMR Spectroscopy of Pyruvate and Amino Acids at Nanomolar to Low Micromolar Concentrations.Analytical chemistry · 2024Article
- LC-Photo-CIDNP hyperpolarization of biomolecules bearing a quasi-isolated spin pair: Magnetic-Field dependence via a rapid-shuttling device.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2024Article
- Detection of sub-nmol amounts of the antiviral drug favipiravir inScientific reports · 2024Article
- Multinuclear 1D and 2D NMR withNature communications · 2023Article
- Spin Hyperpolarization in Modern Magnetic Resonance.Chemical reviews · 2023Review
- Selective Isotope Labeling and LC-Photo-CIDNP Enable NMR Spectroscopy at Low-Nanomolar Concentration.Journal of the American Chemical Society · 2022Article
- Enhanced nuclear-spin hyperpolarization of amino acids and proteins via reductive radical quenchers.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2021Article
- Fast-pulsing LED-enhanced NMR: A convenient and inexpensive approach to increase NMR sensitivity.The Journal of chemical physics · 2019Article
- Improved sensitivity of laser-enhancedJournal of magnetic resonance (San Diego, Calif. : 1997) · 2019Article
- SQUID-based ultralow-field MRI of a hyperpolarized material using signal amplification by reversible exchange.Scientific reports · 2019Article
- Laser- and cryogenic probe-assisted NMR enables hypersensitive analysis of biomolecules at submicromolar concentration.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Chemical Exchange Saturation Transfer in Chemical Reactions: A Mechanistic Tool for NMR Detection and Characterization of Transient Intermediates.Journal of the American Chemical Society · 2018Article
- Pushing nuclear magnetic resonance sensitivity limits with microfluidics and photo-chemically induced dynamic nuclear polarization.Nature communications · 2018Article
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3 authors.
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Abstract
NMR is a powerful yet intrinsically insensitive technique. The applicability of NMR to chemical and biological systems would be substantially extended by new approaches going beyond current signal-to-noise capabilities. Here, we exploit the large enhancements arising from (13)C photochemically induced dynamic nuclear polarization ((13)C photo-CIDNP) in solution to improve biomolecular NMR sensitivity in the context of heteronuclear correlation spectroscopy. The (13)C-PRINT pulse sequence presented here involves an initial (13)C nuclear spin polarization via photo-CIDNP followed by conversion to anti-phase coherence and transfer to (1)H for detection. We observe substantial enhancements, up to ≫200-fold, relative to the dark (laser off) experiment. Resonances of both side-chain and backbone CH pairs are enhanced for the three aromatic residues Trp, His, and Tyr, the σ(32) peptide, and the drkN SH3 protein. The sensitivity of this experiment, defined as signal-to-noise per square root of unit time (S/N)(t), is unprecedented in the NMR polarization enhancement literature dealing with polypeptides in solution. Up to a 16-fold larger (S/N)(t) than for the (1)H-(13)C SE-HSQC reference sequence is achieved, for the σ(32) peptide. Data collection time is reduced up to 256-fold, highlighting the advantages of (1)H-detected (13)C photo-CIDNP in solution NMR.
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