ArticleInternational urology and nephrology2012
Changes in interstitial cell of Cajal-like cells density in congenital ureteropelvic junction obstruction.
Article in International urology and nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Variations in the Density and Distribution of Cajal Like Cells Associated With the Pathogenesis of Ureteropelvic Junction Obstruction: A Systematic Review and Meta-Analysis.Frontiers in surgery · 2021Pooled it
- Article
- Interstitial Cells of Cajal and PJournal of clinical medicine · 2024Article
- Pathological characteristics analysis of children with intermittent and persistent hydronephrosis due to uretero-pelvic junction obstruction.Frontiers in pediatrics · 2024Article
- Article
- Functional Magnetic Resonance Urography in Ureteropelvic Junction Obstruction: Proposal for a Pediatric Quantitative Score.Frontiers in pediatrics · 2022Article
- Is there a difference in the number of interstitial cells, neurons, presence of fibrosis and inflammation in ureteropelvic junction tissues of patients with ureteropelvic junction obstruction with and without crossing vessels?Turkish journal of urology · 2019Article
- The role of HCN channels in peristaltic dysfunction in human ureteral tuberculosis.International urology and nephrology · 2018Article
- Protein Kinase 2Journal of the American Society of Nephrology : JASN · 2018Article
- MMP9 overexpression is associated with good surgical outcome in children with UPJO: Preliminary results.BMC urology · 2016Article
- Laparoscopic pyeloplasty with cephalad translocation of the crossing vessel - a new approach to the Hellström technique.Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniques · 2015Article
- Control of urinary drainage and voiding.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
- Changes in Structure, Interstitial Cajal-like Cells and Apoptosis of Smooth Muscle Cells in Congenital Ureteropelvic Junction Obstruction.Iranian journal of pediatrics · 2014Article
- The distribution of interstitial cells of Cajal in congenital ureteropelvic junction obstruction.International urology and nephrology · 2013Article
- Influence of Interstitial Cells of Cajal in Congenital Ureteropelvic Junction Obstruction.Journal of Indian Association of Pediatric SurgeonsArticle
- Immunohistochemistry in Ureteropelvic Junction Obstruction and Its Correlation to Postoperative Outcome.Journal of Indian Association of Pediatric SurgeonsArticle
- Immunohistochemical and electron microscopic examination of Cajal cells in ureteropelvic junction obstruction.Canadian Urological Association journal = Journal de l'Association des urologues du CanadaArticle
- New Horizon in Understanding of Pediatric Surgical Diseases.Journal of Indian Association of Pediatric SurgeonsArticle
- Evaluation of Interstitial Cells of Cajal-Like Cells at the Pelviureteric Junction in Children with Pelviureteric Junction Obstruction: A Prospective Study and Review of Literature.Journal of Indian Association of Pediatric SurgeonsArticle
- Variation in the Expression of Interstitial Cell of Cajal-like Cell (CD117) Across Congenital Pelvic-ureteric Junction Obstruction and its Renal Sonological and Functional Correlation: A Prospective Observational Study.Journal of Indian Association of Pediatric SurgeonsArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe authors examined the number of interstitial cells of Cajal-like cells (ICC-LCs) in obstructed ureteropelvic junction (UPJ) in comparison with normal UPJ specimens and age-related changes. MATERIALS AND
methodsA total of 20 human formalin fixed, paraffin-embedded specimens of intrinsic UPJO from children at the mean age of 8.1 years (age range: 8 months-16.8 years) and 5 control samples from children at the mean age of 2.3 years (range 2.4 months-7.4 years) were investigated immunohistochemically for the expression of c-kit proto-oncogene by light microscopy with computerized image analysis. The results were examined by Fisher's exact test, Yates' chi-square test, and t test for Pearson's correlation coefficient. A P value less than 0.05 was considered statistically significant.
resultsThe number of ICC-LCs-dense fields was significantly higher in UPJO specimens in comparison with the normal group (P = 0.0004). The number of ICC-LCs-sparse fields was significantly lowered in UPJO specimens in comparison with the normal group (P = 0.0122). There was no significant difference in the number of ICC-LCs-medium fields in obstructed and normal UPJ specimens. The number of ICC-LCs was decreasing significantly with increasing age of the patients with UPJO (P = 0.0038).
conclusionsThe higher density of c-kit-positive ICC-LCs in UPJ may manifest the compensation of altered peristalsis in UPJO. The number of ICC-LCs-dense fields decreasing with age may show the failure of compensation and regression of the compensatory changes.
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