ArticlePediatric nephrology (Berlin, Germany)2011
Neurological development in 21 children on peritoneal dialysis in infancy.
Article in Pediatric nephrology (Berlin, Germany), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- Development of Non-HLA Antibodies and Their Association With Antibody-Mediated Rejection in Pediatric Kidney Transplant Recipients.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Study of the association between generic and disease-specific quality of life and behavior problems in pediatric patients with chronic kidney disease stage 3 or higher and the quality of life and mental health of their primary caregivers.Pediatric nephrology (Berlin, Germany) · 2021Article
- Congenital nephrotic syndrome: is early aggressive treatment needed? Yes.Pediatric nephrology (Berlin, Germany) · 2020Review
- Outcomes of infants receiving chronic peritoneal dialysis: an analysis of the USRDS registry.Pediatric nephrology (Berlin, Germany) · 2019Article
- Long-term hemodialysis therapy in neonates and infants with end-stage renal disease: a 16-year experience and outcome.Pediatric nephrology (Berlin, Germany) · 2016Article
- Parent-child and spousal relationships in families with a young child with end-stage renal disease.Pediatric nephrology (Berlin, Germany) · 2014Article
- Long-term neurocognitive outcomes of patients with end-stage renal disease during infancy.Pediatric nephrology (Berlin, Germany) · 2013Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Few studies have focused on the neurodevelopment of infants on peritoneal dialysis (PD). Infants are the most demanding patient group on PD and thus are vulnerable to neurological sequelae. We studied 21 patients <2 years of age (mean 0.59 years) at onset of PD. They were evaluated by a neurologist, otologist, physiotherapist, and occupational therapist during PD. Neuropsychological tests were collected from all patients at least 5 years old, and the brain images were reviewed. Eleven patients (52%) had a pre- or neonatal problem or comorbidity as risk factor for their development at onset of PD. All infants tolerated PD well. At the end of the study, 71% had some neurological abnormality, 29% a major impairment (all with predialysis risk factors), and 43% a minor one. Brain infarcts were detected in four patients (19%) and other ischemic lesions in three (14%). Three patients (14%) developed hearing defect. Mortality rate was 5%. PD is a safe treatment modality for end-stage renal failure in infants. Some patients had risk factors for development, but their neurological problems did not progress during PD. Patients without risk factors tolerated PD well without major neurological sequelae.
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