ArticleInternational journal of Alzheimer's disease2011
The Role of GSK3 in Presynaptic Function.
Article in International journal of Alzheimer's disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- TCF-1 regulates NKG2D expression on CD8 T cells during anti-tumor responses.Cancer immunology, immunotherapy : CII · 2023Article
- Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4Emerging microbes & infections · 2022Article
- GSK-3Neural plasticity · 2019Review
- Glycogen synthase kinase 3 beta regulates ethanol consumption and is a risk factor for alcohol dependence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Voltage-gated sodium currents in cerebellar Purkinje neurons: functional and molecular diversity.Cellular and molecular life sciences : CMLS · 2018Review
- Article
- Gsk3 Signalling and Redox Status in Bipolar Disorder: Evidence from Lithium Efficacy.Oxidative medicine and cellular longevity · 2016Review
- Herpes Simplex Virus type-1 infection induces synaptic dysfunction in cultured cortical neurons via GSK-3 activation and intraneuronal amyloid-β protein accumulation.Scientific reports · 2015Article
- Crosstalk between Akt/GSK3β signaling and dynamin-1 regulates clathrin-mediated endocytosis.The EMBO journal · 2015Article
- Article
- Altered expression of histone and synaptic plasticity associated genes in the hippocampus of streptozotocin-induced diabetic mice.Metabolic brain disease · 2013Article
- Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase.Molecular brain · 2013Article
- Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2.Trends in neurosciences · 2012Review
- Control of neuronal ion channel function by glycogen synthase kinase-3: new prospective for an old kinase.Frontiers in molecular neuroscience · 2012Article
- Modulation of GSK-3 as a Therapeutic Strategy on Tau Pathologies.Frontiers in molecular neuroscience · 2011Article
- GSK3 and Alzheimer's Disease: Facts and Fiction….Frontiers in molecular neuroscience · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The past ten years of research have identified a number of key roles for glycogen synthase kinase 3 (GSK3) at the synapse. In terms of presynaptic physiology, critical roles for GSK3 have been revealed in the growth and maturation of the nerve terminal and more recently a key role in the control of activity-dependent bulk endocytosis of synaptic vesicles. This paper will summarise the major roles assigned to GSK3 in both immature and mature nerve terminals, the substrates GSK3 phosphorylates to exert its action, and how GSK3 activity is regulated by different presynaptic signalling cascades. The number of essential roles for GSK3, coupled with the numerous signalling cascades all converging to regulate its activity, suggests that GSK3 is a key integrator of multiple inputs to modulate the strength of neurotransmission. Modulation of these pathways may point to potential mechanisms to overcome synaptic failure in neurodegenerative disorders such as Alzheimer's disease.
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Registered trials
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