ArticleWorld journal of gastroenterology2011
Ku80 gene G-1401T promoter polymorphism and risk of gastric cancer.
Article in World journal of gastroenterology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 7 citations in OpenAlex.
- XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi-center study.Cancer medicine · 2021Article
- Review
- Association between IRS-2 G1057D polymorphism and risk of gastric cancer.World journal of gastrointestinal oncology · 2012Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
aimTo evaluate the possible relationship between the Ku80 gene polymorphism and the risk of gastric cancer in China.
methodsIn this hospital-based case-control study of gastric cancer in Jiangsu Province, China, we investigated the association of the Ku80 G-1401T (rs828907) polymorphism with gastric cancer risk. A total of 241 patients with gastric cancer and 273 age- and sex-matched control subjects were genotyped and analyzed by polymerase chain reaction-restriction fragment length polymorphism.
resultsThe frequencies of genotypes GG, GT and TT were 65.6%, 22.8% and 11.6% in gastric cancer cases, respectively, and 75.8%, 17.6% and 6.6% in controls, respectively. There were significant differences between gastric cancer and control groups in the distribution of their genotypes (P = 0.03) and allelic frequencies (P = 0.002) in the Ku80 promoter G-1401T polymorphism.
conclusionThe T allele of Ku80 G-1401T may be associated with the development of gastric cancer.
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