ArticleDermato-endocrinology2010
An ecological study of cancer incidence and mortality rates in France with respect to latitude, an index for vitamin D production.
Article in Dermato-endocrinology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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The trial behind it
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The effects of sunlight exposure on mortality: a systematic review of epidemiological studies.NIHR open research · 2025Pooled it
- Vitamin D and VDR in Gynecological Cancers-A Systematic Review.International journal of molecular sciences · 2017Pooled it
- Association of Vitamin D Status With Total and Site-Specific Cancer Mortality From Tropical to Subantarctic Latitudes: A Nationwide Population-Based Study in Chile.Cancer medicine · 2026Article
- Vitamin D and Its Receptors in Cervical Cancer.Journal of Cancer · 2024Review
- The Preventive Role of the Vitamin D Endocrine System in Cervical Cancer.International journal of molecular sciences · 2023Review
- Geographic variation in urinary tract and genital cancers in Iran: a hypothesis involving exposure to solar radiation.BMC research notes · 2023Article
- Cutaneous malignant melanoma incidence is strongly associated with European depigmented skin type regardless of ambient ultraviolet radiation levels: evidence from Worldwide population-based data.AIMS public health · 2022Article
- The association of gastrointestinal cancers (esophagus, stomach, and colon) with solar ultraviolet radiation in Iran-an ecological study.Environmental monitoring and assessment · 2019Article
- SNPs related to vitamin D and breast cancer risk: a case-control study.Breast cancer research : BCR · 2018Article
- Vitamin D-related gene polymorphisms, plasma 25-hydroxyvitamin D, and breast cancer risk.Cancer causes & control : CCC · 2015Article
- Article
- Serum levels of vitamin D, parathyroid hormone and calcium in relation to survival following breast cancer.Cancer causes & control : CCC · 2014Article
- Sunlight exposure during leisure activities and risk of prostate cancer in Montréal, Canada, 2005-2009.BMC public health · 2014Article
- Seasonality pattern of breast, colorectal, and prostate cancer is dependent on latitude.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- Sun exposure, vitamin D receptor genetic variants, and risk of breast cancer in the Agricultural Health Study.Environmental health perspectives · 2014Article
- Molecular link between vitamin D and cancer prevention.Nutrients · 2013Review
- Vitamin D receptor gene haplotypes and polymorphisms and risk of breast cancer: a nested case-control study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
- An estimate of the global reduction in mortality rates through doubling vitamin D levels.European journal of clinical nutrition · 2011Review
- Dermato-Endocrinology remembers Dr. Frank C. Garland: A great scientist who made major contributions to improve our understanding about the importance of vitamin D for human health!Dermato-endocrinology · 2010Article
- The role of geographical ecological studies in identifying diseases linked to UVB exposure and/or vitamin D.Dermato-endocrinologyReview
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
France has unexplained large latitudinal variations in cancer incidence and mortality rates. Studies of cancer rate variations in several other countries, as well as in multicountry studies, have explained such variations primarily in terms of gradients in solar ultraviolet-B (UVB) doses and vitamin D production. To investigate this possibility in France, I obtained data on cancer incidence and mortality rates for 21 continental regions and used this information in regression analyses with respect to latitude. This study also used dietary data. Significant positive correlations with latitude emerged for breast, colorectal, esophageal (males), lung (males), prostate, both uterine cervix and uterine corpus, all and all less lung cancer. Although correlations with latitude were similar for males and females, the regression variance for all and all less lung cancer was about twice as high for males than for females. Lung cancer incidence and mortality rates for females had little latitudinal gradient, indicating that smoking may have also contributed to the latitudinal gradients for males. On the basis of the available dietary factor, micro- and macronutrient data, dietary differences do not significantly affect geographical variation in cancer rates. These results are consistent with solar UVB's reducing the risk of cancer through production of vitamin D. In the context of serum 25-hydroxyvitamin D level-cancer incidence relations, cancer rates could be reduced significantly in France if everyone obtained an additional 1,000 IU/day of vitamin D. Many other benefits of vitamin D exist as well.
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