ReviewEMBO reports2011
Cease and desist: modulating short-range Dpp signalling in the stem-cell niche.
Review in EMBO reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed.
- PIWI proteins and piRNAs: key regulators of stem cell biology.Frontiers in cell and developmental biology · 2025Review
- Single-cell expression profile of Drosophila ovarian follicle stem cells illuminates spatial differentiation in the germarium.BMC biology · 2023Article
- Analysis of a rare progeria variant of Barrier-to-autointegration factor in Drosophila connects centromere function to tissue homeostasis.Cellular and molecular life sciences : CMLS · 2023Article
- Novel intrinsic factor Yun maintains female germline stem cell fate through Thickveins.Stem cell reports · 2022Article
- brinker levels regulated by a promoter proximal element support germ cell homeostasis.Development (Cambridge, England) · 2022Article
- Adult stem cells and niche cells segregate gradually from common precursors that build the adulteLife · 2021Article
- Diversity and robustness of bone morphogenetic protein pattern formation.Development (Cambridge, England) · 2021Review
- Molecular and biological functions of TRIM-NHL RNA-binding proteins.Wiley interdisciplinary reviews. RNA · 2021Review
- Nuclear architecture as an intrinsic regulator of Drosophila female germline stem cell maintenance.Current opinion in insect science · 2020Review
- Loss of putzig in the germline impedes germ cell development by inducing cell death and new niche like microenvironments.Scientific reports · 2019Article
- N-linked glycosylation restricts the function of Short gastrulation to bind and shuttle BMPs.Development (Cambridge, England) · 2018Article
- Smad-Independent BMP Signaling in Somatic Cells Limits the Size of the Germline Stem Cell Pool.Stem cell reports · 2018Article
- Identification of target genes regulated by the Drosophila histone methyltransferase Eggless reveals a role of Decapentaplegic in apoptotic signaling.Scientific reports · 2018Article
- Combinatorial control of messenger RNAs by Pumilio, Nanos and Brain Tumor Proteins.RNA biology · 2017Article
- The TGF-β Family in the Reproductive Tract.Cold Spring Harbor perspectives in biology · 2017Review
- Yorkie and Hedgehog independently restrict BMP production in escort cells to permit germline differentiation in theDevelopment (Cambridge, England) · 2017Article
- Control of signaling molecule range during developmental patterning.Cellular and molecular life sciences : CMLS · 2017Review
- Identification of Development-Related Genes in the Ovaries of Adult Harmonia axyridis (Pallas) Lady Beetles Using a Time- Series Analysis by RNA-seq.Scientific reports · 2016Article
- Drosophila male and female germline stem cell niches require the nuclear lamina protein Otefin.Developmental biology · 2016Article
- The Drosophila tricellular junction protein Gliotactin regulates its own mRNA levels through BMP-mediated induction of miR-184.Journal of cell science · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Drosophila ovarian germline stem cells (GSCs) are maintained by the extracellular BMP2/4 orthologue Dpp, which is produced from the surrounding somatic niche. The Dpp signal has a short range; it induces a response in GSCs within the niche, but is rapidly extinguished in their progeny only one cell-diameter away. To ensure the correct balance between stem-cell maintenance and differentiation, several regulatory mechanisms that modulate the Dpp signal at many stages of the pathway have been described. Here, we discuss the nature of the ovarian Dpp signal and review the catalogue of mechanisms that regulate it, demonstrating how the exquisite modulation of Dpp signalling in this context can result in precise and robust control of stem-cell fate. This modulation is applicable to other stem-cell environments that use BMPs as a niche signal, and the regulatory mechanisms are conceptually relevant to several other stem-cell systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.