ArticleJournal of acquired immune deficiency syndromes (1999)2011
Early postseroconversion CD4 cell counts independently predict CD4 cell count recovery in HIV-1-postive subjects receiving antiretroviral therapy.
Article in Journal of acquired immune deficiency syndromes (1999), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Predictors of change in CD4 cell count over time for HIV/AIDS patients on ART follow-up in northern Ethiopia: a retrospective longitudinal study.BMC immunology · 2024Article
- Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART.PLoS pathogens · 2021Article
- Plasma MicroRNA Signature Panel Predicts the Immune Response After Antiretroviral Therapy in HIV-Infected Patients.Frontiers in immunology · 2021Article
- Socio-Demographic, Economic and Clinical Predictors for HAART Adherence Competence in HIV-Positive Adults at Felege Hiwot Teaching and Specialized Hospital, North West Ethiopia.HIV/AIDS (Auckland, N.Z.) · 2021Article
- Determinants of suboptimal CD4Journal of the International AIDS Society · 2020Article
- Multilevel ordinal model for CD4 count trends in seroconversion among South Africa women.BMC infectious diseases · 2020Article
- Determinants of Restoration of CD4 and CD8 Cell Counts and Their Ratio in HIV-1-Positive Individuals With Sustained Virological Suppression on Antiretroviral Therapy.Journal of acquired immune deficiency syndromes (1999) · 2019Article
- Cumulative viral load as a predictor of CD4+ T-cell response to antiretroviral therapy using Bayesian statistical models.PloS one · 2019Article
- Growing up with perinatal HIV: changes in clinical outcomes before and after transfer to adult care in the UK.Journal of the International AIDS Society · 2017Article
- Association between hepatitis B vaccine antibody response and CD4 reconstitution after initiation of combination antiretroviral therapy in HIV-infected persons.BMC infectious diseases · 2015Article
- Influence of the timing of antiretroviral therapy on the potential for normalization of immune status in human immunodeficiency virus 1-infected individuals.JAMA internal medicine · 2015Observational
- CCL3L1 copy number, HIV load, and immune reconstitution in sub-Saharan Africans.BMC infectious diseases · 2013Article
- Predictors of CD4:CD8 ratio normalization and its effect on health outcomes in the era of combination antiretroviral therapy.PloS one · 2013Article
- Assessment of the impact of adherence and other predictors during HAART on various CD4 cell responses in resource-limited settings.Patient preference and adherence · 2012Article
- Article
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
backgroundThe relationship between CD4 T-cell counts determined soon after seroconversion with HIV-1 (baseline CD4), nadir CD4, and CD4 levels attained during highly active antiretroviral therapy (HAART) is unknown.
methodsLongitudinal, including baseline (at or soon after HIV diagnosis), intermediate (nadir), and distal (post-HAART) CD4 T-cell counts were assessed in 1085 seroconverting subjects who achieved viral load suppression from a large well-characterized cohort. The association of baseline with post-HAART CD4 T-cell count was determined after adjustment for other relevant covariates.
resultsA higher baseline CD4 T-cell count predicted a greater post-HAART CD4 T-cell count, independent of the nadir and other explanatory variables. Together, baseline and nadir strongly predicted the post-HAART CD4 count such that a high baseline and lower nadir were associated with a maximal immune recovery after HAART. Likelihood of recovery of the baseline count after HAART was significantly higher when the nadir/baseline count ratio was consistently ≥ 0.6.
conclusionsAmong viral load suppressing seroconverters, the absolute CD4 T-cell count attained post-HAART is highly dependent on both baseline and nadir CD4 T-cell counts. These associations further support the early diagnosis and initiation of HAART among HIV-infected persons.
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