ArticleMolecular and cellular biology1990
Regulation of DdrasG gene expression during Dictyostelium development.
Article in Molecular and cellular biology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- IQGAP-related protein IqgC suppresses Ras signaling during large-scale endocytosis.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Determinants of RasC specificity during Dictyostelium aggregation.The Journal of biological chemistry · 2010Article
- Cytoskeletal regulation by Dictyostelium Ras subfamily proteins.Journal of muscle research and cell motility · 2002Review
- Dictyostelium RasD is required for normal phototaxis, but not differentiation.Genes & development · 2000Article
- Rapid changes of nucleotide excision repair gene expression following UV-irradiation and cisplatin treatment of Dictyostelium discoideum.Nucleic acids research · 1998Article
- Dictyostelium RasG is required for normal motility and cytokinesis, but not growth.The Journal of cell biology · 1997Article
- Overexpression of an activated rasG gene during growth blocks the initiation of Dictyostelium development.Molecular and cellular biology · 1996Article
- Basidiomycetous ras cDNA functionally replaces its homolog genes in yeast.Current genetics · 1994Article
- Biochemical characterization of Artemia ras p21.Molecular and cellular biochemistry · 1992Article
- Dual role of GDP in the regulation of the levels of p36 phosphorylation in Dictyostelium discoideum.Journal of protein chemistry · 1991Article
- A developmentally regulated gene encodes the dictyostelium homolog of yeast ribosomal protein S4 and mammalian LLRep3 proteins.Nucleic acids research · 1991Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DdrasG gene expression during the early development of Dictyostelium discoideum has been examined in detail. The amount of DdrasG-specific mRNA increased approximately twofold during the first 2 to 3 h of development and then declined rapidly, reaching negligible levels by the aggregation stage. The increase in mRNA levels that occurred during the first 2 to 3 h of development also occurred during differentiation in cell suspensions and was enhanced when cells were shaken rapidly. This initial increase was unaffected by cell density. When cells were set up to differentiate on filters, the addition of a glucose-amino acid mixture slightly delayed differentiation and had a similar effect on the expression of the gene. The decline in DdrasG expression during development did not occur when cells were treated with cycloheximide, suggesting that the expression of a developmentally regulated gene product is essential for the reduction of DdrasG gene mRNA. There was no decrease in DdrasG mRNA level during differentiation in shake suspension, but the decrease did occur upon application of pulses of cyclic AMP to shaking cultures. The application of a continuously high level of cyclic AMP delayed the increase in expression of the gene and did not result in the subsequent decline. These results suggest that the induction of a functional cyclic AMP relay system is important in reducing DdrasG gene mRNA levels.
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