ArticleHaematologica2011
Reassessment of small lymphocytic lymphoma in the era of monoclonal B-cell lymphocytosis.
Article in Haematologica, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- Guidelines for Diagnosis and Treatment of Chronic Lymphocytic Leukemia. Krohem B-Cll 2017.Acta clinica Croatica · 2018Guideline
- Pure Nodal Small Lymphocytic Lymphoma: Clinical, Pathologic, and Outcome Features in a Single-Center Cohort.Medicina (Kaunas, Lithuania) · 2026Observational
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- Chronic lymphocytic leukaemia/small lymphocytic lymphoma and mantle cell lymphoma: from early lesions to transformation.Virchows Archiv : an international journal of pathology · 2023Review
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- Prescription of Blood Lymphocyte Immunophenotyping in the Diagnosis of Lymphoid Neoplasms in Older Adults.Journal of clinical medicine · 2022Article
- How to Diagnose and Treat CD5-Positive Lymphomas Involving the Spleen.Current oncology (Toronto, Ont.) · 2021Review
- Erdheim-Chester Disease and Small Lymphocytic Lymphoma Collision Tumour Presenting as a Perirenal Mass.Case reports in pathology · 2020Article
- [Revised version of the 4th edition of the WHO classification of malignant lymphomas : What is new?]Der Pathologe · 2019Review
- Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and T-Prolymphocytic Leukemia Presenting with Lymphocytosis, Skin Lesions, and Generalized Lymphadenopathy.Case reports in pathology · 2019Article
- Clinical Impact of the 2016 Update to the WHO Lymphoma Classification.Current treatment options in oncology · 2017Review
- The 2016 revision of the World Health Organization classification of lymphoid neoplasms.Blood · 2016Review
- The many faces of small B cell lymphomas with plasmacytic differentiation and the contribution of MYD88 testing.Virchows Archiv : an international journal of pathology · 2016Review
- Review
- Early lymphoid lesions: conceptual, diagnostic and clinical challenges.Haematologica · 2014Review
- Monoclonal B-cell lymphocytosis in donors.Blood · 2014Article
- Primary gallbladder small lymphocytic lymphoma as a rare postcholecystectomy finding.Case reports in hematology · 2014Article
- Monoclonal B-cell lymphocytosis.Translational medicine @ UniSa · 2014Article
- Increased CD5-positive polyclonal B cells in Castleman disease: a diagnostic pitfall.Histopathology · 2013Article
- [In situ lymphoma and other early stage malignant non-Hodgkin lymphomas].Der Pathologe · 2013Review
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7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIn the 2008 World Health Organization classification, small lymphocytic lymphoma is defined as a neoplasm with the tissue morphology and immunophenotype of chronic lymphocytic leukemia, but with absence of leukemia. Minimal criteria of tissue involvement to separate small lymphocytic lymphoma from monoclonal B-cell lymphocytosis have not been defined. DESIGN AND
methodsWe reviewed the clinicopathological features of 36 patients with extramedullary tissue biopsies containing chronic lymphocytic leukemia-type cells and less than 5×10(9)/L peripheral blood monoclonal B cells. Pathological features (extent and patterns of involvement, architectural preservation, presence of proliferation centers) as well as cytogenetic and radiological findings were examined in relation to clinical outcome.
resultsThe biopsies were performed to evaluate lymphadenopathy in 20 patients and for other reasons (most frequently staging of a non-hematologic neoplasm) in 16 patients. At latest follow-up (median 23 months), 21 untreated patients had no or stable lymphadenopathy, 3 had regressed lymphadenopathy, and 12 had developed progressive lymphadenopathy and/or received therapy for chronic lymphocytic leukemia/small lymphocytic lymphoma. Features associated with progression/treatment included lymph nodes 1.5 cm or greater on imaging studies (P=0.01) and presence of proliferation centers in the biopsied tissue (P=0.004). Neither the size nor extent of involvement of the excised lymph node correlated with progression/treatment.
conclusionsOur findings suggest that biopsies containing chronic lymphocytic leukemia-type cells, but lacking proliferation centers and with non-enlarged or only slightly enlarged lymph nodes on imaging, represent a very indolent disease that may best be considered a tissue equivalent of monoclonal B-cell lymphocytosis rather than overt small lymphocytic lymphoma. We propose that such cases be designated as tissue involvement by chronic lymphocytic leukemia/small lymphocytic lymphoma-like cells of uncertain significance.
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