Evidence map›Paper›PMID 21546411›Full record

ReviewMolecular endocrinology (Baltimore, Md.)2011

Minireview: The roles of small RNA pathways in reproductive medicine.

Shannon M Hawkins, Gregory M Buchold, Martin M Matzuk

Open access · greenAbstract readReview
In one paragraph

Review in Molecular endocrinology (Baltimore, Md.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. MicroRNAs: key regulators of the trophoblast function in pregnancy disorders.Journal of assisted reproduction and genetics · 2023
    Review
  2. Review
  3. Article
  4. Structural basis for arginine methylation-independent recognition of PIWIL1 by TDRD2.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  5. Review
  6. Article
  7. Article
  8. Molecular Regulation of Parturition: A Myometrial Perspective.Cold Spring Harbor perspectives in medicine · 2015
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Shannon M HawkinsDepartment of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas 77030, USA. shannonh@bcm.edu
Gregory M Buchold
Martin M Matzuk
Baylor College of Medicine · USNational Institutes of Health · US

Funding

Transforming growth factor β family signaling pathways in ovarian and uterine biologyR01HD032067 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MARTIN M. MATZUK · 1994 to 2026
$9.9M
REPRODUCTIVE BIOLOGY: REGULATORY MECHANISMST32HD007165 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI O'MALLEY, BERT W · 1985 to 2015
$5.6M
MOUSE MODELS TO STUDY GONADAL TUMOR DEVELOPMENTR01CA060651 · NCI · BAYLOR COLLEGE OF MEDICINE · PI MATZUK, MARTIN M. · 1993 to 2010
$3.2M
REPRODUCTIVE FUNCTION USING TRANSGENIC MICER01HD033438 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MATZUK, MARTIN M. · 1996 to 2015
$2.5M
Baylor WRHR ProgramK12HD050128 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI BROWN, DALE · 2005 to 2009
$1.8M
identification of small molecule contraceptives that target the male germlineU01HD060496 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI MATZUK, MARTIN M. · 2009 to 2013
$1.2M
Effectiveness and Patient Selection in Post-Hospital Brain Injury RehabilitationR03HD077495 · NICHD · INDIANA UNIVERSITY INDIANAPOLIS · PI MALEC, JAMES F. · 2014 to 2015
$154k
NCI NIH HHS R01 CA060651NCI NIH HHS R01CA060651NICHD NIH HHS 5K12HD050128NICHD NIH HHS 5T32HD007165NICHD NIH HHS K12 HD050128NICHD NIH HHS R01 HD032067NICHD NIH HHS R01 HD033438NICHD NIH HHS R01HD033438NICHD NIH HHS R03 HD077495NICHD NIH HHS T32 HD007165NICHD NIH HHS U01 HD060496NICHD NIH HHS U01HD060496NICHD NIH HHS U54HD0077495
6 · The paper itself

Abstract

The discovery of small noncoding RNA, including P-element-induced wimpy testis-interacting RNA, small interfering RNA, and microRNA, has energized research in reproductive medicine. In the two decades since the identification of small RNA, first in Caenorhabditis elegans and then in other animals, scientists in many disciplines have made significant progress in elucidating their biology. A powerful battery of tools, including knockout mice and small RNA mimics and antagonists, has facilitated investigation into the functional roles and therapeutic potential of these small RNA pathways. Current data indicate that small RNA play significant roles in normal development and physiology and pathological conditions of the reproductive tracts of females and males. Biologically plausible mRNA targets for these microRNA are aggressively being discovered. The next phase of research will focus on elucidating the clinical utility of small RNA-selective agonists and antagonists.

Indexed as

Reproductive MedicineAnimalsGerm CellsHumansMicroRNAsTranslational Research, BiomedicalUrogenital SystemMicroRNAs

Identifiers

PMID21546411
PMCPMC3146245
OpenAlexW1978409298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.