Evidence map›Paper›PMID 21546393›Full record

ArticleBioinformatics (Oxford, England)2011

Molecular signatures database (MSigDB) 3.0.

Arthur Liberzon, Aravind Subramanian, Reid Pinchback, Helga Thorvaldsdóttir, Pablo Tamayo, Jill P Mesirov

Registry-linked trialAbstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07233915 (Genetic Profile in Patients With Ruptured and Unruptured Intracranial Aneurysms), which is not on this map. Cited by 4,782 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4,782citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07233915 recruitingnot on this mapstarted 2014, after this paper: background citation

Genetic Profile in Patients With Ruptured and Unruptured Intracranial Aneurysms: Observational Study Aimed at Identifying Genetic Variants Associated With the Risk of Intracranial Aneurysm Rupture

TypeobservationalSponsorFondazione I.R.C.C.S. Istituto Neurologico Carlo BestaRan2014 to 2027Enrolled252ConditionsAneurism
3 · Its place in the literature

Who cites it

4,782 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
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  5. Pathway and Kinase Analysis in Proteomics and Phosphoproteomics with rROMA.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
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  11. Virulence · 2026
    Article
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  13. Latent causal diffusions for single-cell perturbation modeling.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. Article
  15. EML4-ALK fusion rewires transcriptomic, miRNA, and CAF-associated programs in non-small cell lung cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026
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4,722 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arthur LiberzonBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Aravind Subramanian
Reid Pinchback
Helga Thorvaldsdóttir
Pablo Tamayo
Jill P Mesirov

Funding

Knowledge-based Gene Expression Analysis for Biomedical and Cancer ResearchR01CA121941 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MESIROV, JILL P. · 2006 to 2016
$5.1M
NCI NIH HHS 5R01CA121941NCI NIH HHS R01 CA121941
6 · The paper itself

Abstract

motivationWell-annotated gene sets representing the universe of the biological processes are critical for meaningful and insightful interpretation of large-scale genomic data. The Molecular Signatures Database (MSigDB) is one of the most widely used repositories of such sets.

resultsWe report the availability of a new version of the database, MSigDB 3.0, with over 6700 gene sets, a complete revision of the collection of canonical pathways and experimental signatures from publications, enhanced annotations and upgrades to the web site. AVAILABILITY AND IMPLEMENTATION: MSigDB is freely available for non-commercial use at http://www.broadinstitute.org/msigdb.

Indexed as

Databases, GeneticGenomicsInternetMolecular Sequence Annotation

Identifiers

PMID21546393
PMCPMC3106198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.