ArticleJournal of cellular and molecular medicine2012
Proteomic analysis of metabolic, cytoskeletal and stress response proteins in human heart failure.
Article in Journal of cellular and molecular medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 40 citations in OpenAlex.
- Metrics of left ventricular active relaxation reflect proteomic myocardial remodelling and reverse remodelling.ESC heart failure · 2026Article
- The diabetic myocardial transcriptome reveals Erbb3 and Hspa2 as a novel biomarkers of incident heart failure.Cardiovascular research · 2024Article
- Proteome-wide Characterization and Pathophysiology Correlation in Non-ischemic Cardiomyopathies.Korean circulation journal · 2024Article
- Mitochondrial heterogeneity in diseases.Signal transduction and targeted therapy · 2023Review
- Proteomic and phosphoproteomic profiling in heart failure with preserved ejection fraction (HFpEF).Frontiers in cardiovascular medicine · 2022Article
- Multi-omics integration identifies key upstream regulators of pathomechanisms in hypertrophic cardiomyopathy due to truncating MYBPC3 mutations.Clinical epigenetics · 2021Article
- Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy.Journal of molecular and cellular cardiology · 2020Article
- Landscape of heart proteome changes in a diet-induced obesity model.Scientific reports · 2019Article
- Screening for key genes and transcription factors in ankylosing spondylitis by RNA-Seq.Experimental and therapeutic medicine · 2018Article
- Different Transcriptomic Responses to Thermal Stress in Heat-Tolerant and Heat-Sensitive Pacific Abalones Indicated by Cardiac Performance.Frontiers in physiology · 2018Article
- Monoamine Oxidase Is Overactivated in Left and Right Ventricles from Ischemic Hearts: An Intriguing Therapeutic Target.Oxidative medicine and cellular longevity · 2016Article
- Right ventricular protein expression profile in end-stage heart failure.Pulmonary circulation · 2015Article
- ATP synthase subunit alpha and LV mass in ischaemic human hearts.Journal of cellular and molecular medicine · 2015Article
- Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins.The Journal of cell biology · 2014Article
- Article
- Novel proteins associated with human dilated cardiomyopathy: selective reduction in α(1A)-adrenergic receptors and increased desensitization proteins.Journal of receptor and signal transduction research · 2013Article
- Reversible inactivation of dihydrolipoamide dehydrogenase by mitochondrial hydrogen peroxide.Free radical research · 2013Article
- Characterization of hsp27 kinases activated by elevated aortic pressure in heart.Molecular and cellular biochemistry · 2012Article
- Cardiac protein changes in ischaemic and dilated cardiomyopathy: a proteomic study of human left ventricular tissue.Journal of cellular and molecular medicine · 2012Article
- Systems proteomics for translational network medicine.Circulation. Cardiovascular genetics · 2012Article
Corrections and comments
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Authors and funding
12 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human heart failure is a complex syndrome and a primary cause of morbidity and mortality in the world. However, the molecular pathways involved in the remodelling process are poorly understood. In this study, we performed exhaustive global proteomic surveys of cardiac ventricle isolated from failing and non-failing human hearts, and determined the regulatory pathway to uncover the mechanism underlying heart failure. Two-dimensional gel electrophoresis (2-DE) coupled with tandem mass spectrometry was used to identify differentially expressed proteins in specimens from failing (n = 9) and non-failing (n = 6) human hearts. A total of 25 proteins with at least 1.5-fold change in the failing heart were identified; 15 proteins were up-regulated and 10 proteins were down-regulated. The altered proteins belong to three broad functional categories: (i) metabolic [e.g. NADH dehydrogenase (ubiquinone), dihydrolipoamide dehydrogenase, and the cytochrome c oxidase subunit]; (ii) cytoskeletal (e.g. myosin light chain proteins, troponin I type 3 and transthyretin) and (iii) stress response (e.g. αB-crystallin, HSP27 and HSP20). The marked differences in the expression of selected proteins, including HSP27 and HSP20, were further confirmed by Western blot. Thus, we carried out full-scale screening of the protein changes in human heart failure and profiled proteins that may be critical in cardiac dysfunction for future mapping.
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