ArticleThe Biochemical journal2011
A scaffold of accessory subunits links the peripheral arm and the distal proton-pumping module of mitochondrial complex I.
Article in The Biochemical journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 84 citations in OpenAlex.
- Mitochondrial DNA Dysfunction in Cardiovascular Diseases: A Novel Therapeutic Target.Antioxidants (Basel, Switzerland) · 2025Review
- Resting mitochondrial complex I fromeLife · 2023Article
- The Mysterious Multitude: Structural Perspective on the Accessory Subunits of Respiratory Complex I.Frontiers in molecular biosciences · 2021Review
- Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation.Nature structural & molecular biology · 2020Article
- Multisystem mitochondrial diseases due to mutations in mtDNA-encoded subunits of complex I.BMC pediatrics · 2020Article
- CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain.Cancer & metabolism · 2019Article
- Pathogenic mutations in NUBPL affect complex I activity and cold tolerance in the yeast model Yarrowia lipolytica.Human molecular genetics · 2018Article
- Respiratory chain Complex I of unparalleled divergence in diplonemids.The Journal of biological chemistry · 2018Article
- Article
- Cytonuclear integration and co-evolution.Nature reviews. Genetics · 2018Review
- Purification of Ovine Respiratory Complex I Results in a Highly Active and Stable Preparation.The Journal of biological chemistry · 2016Article
- Life without complex I: proteome analyses of an Arabidopsis mutant lacking the mitochondrial NADH dehydrogenase complex.Journal of experimental botany · 2016Article
- Structure of subcomplex Iβ of mammalian respiratory complex I leads to new supernumerary subunit assignments.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Accessory NUMM (NDUFS6) subunit harbors a Zn-binding site and is essential for biogenesis of mitochondrial complex I.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency.Journal of inherited metabolic disease · 2015Review
- Parallel Structural Evolution of Mitochondrial Ribosomes and OXPHOS Complexes.Genome biology and evolution · 2015Article
- Mutations in NDUFB11, encoding a complex I component of the mitochondrial respiratory chain, cause microphthalmia with linear skin defects syndrome.American journal of human genetics · 2015Article
- Review
- Architecture of mammalian respiratory complex I.Nature · 2014Article
- ND3, ND1 and 39kDa subunits are more exposed in the de-active form of bovine mitochondrial complex I.Biochimica et biophysica acta · 2014Article
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Mitochondrial NADH:ubiquinone oxidoreductase (complex I) is a very large membrane protein complex with a central function in energy metabolism. Complex I from the aerobic yeast Yarrowia lipolytica comprises 14 central subunits that harbour the bioenergetic core functions and at least 28 accessory subunits. Despite progress in structure determination, the position of individual accessory subunits in the enzyme complex remains largely unknown. Proteomic analysis of subcomplex Iδ revealed that it lacked eleven subunits, including the central subunits ND1 and ND3 forming the interface between the peripheral and the membrane arm in bacterial complex I. This unexpected observation provided insight into the structural organization of the connection between the two major parts of mitochondrial complex I. Combining recent structural information, biochemical evidence on the assignment of individual subunits to the subdomains of complex I and sequence-based predictions for the targeting of subunits to different mitochondrial compartments, we derived a model for the arrangement of the subunits in the membrane arm of mitochondrial complex I.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.