ArticleRadiation research2011
AT1 receptor antagonism does not influence early radiation-induced changes in microglial activation or neurogenesis in the normal rat brain.
Article in Radiation research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- Renin-angiotensin system as an emerging target to modulate adult neurogenesis in health and disease.Stem cell research & therapy · 2025Review
- The current research status of the mechanisms and treatment of radioactive brain injury.American journal of cancer research · 2024Review
- Pathogenic mechanisms and therapeutic promise of phytochemicals and nanocarriers based drug delivery against radiotherapy-induced neurotoxic manifestations.Drug delivery · 2022Review
- Assessment of cellular and molecular changes in the rat brain after gamma radiation and radioprotection by anisomycin.Journal of radiation research · 2021Article
- Can Dexmedetomidine Be Effective in the Protection of Radiotherapy-Induced Brain Damage in the Rat?Neurotoxicity research · 2021Article
- Modulation of the Nitric Oxide/BH4 Pathway Protects Against Irradiation-Induced Neuronal Damage.Neurochemical research · 2021Article
- An Iatrogenic Model of Brain Small-Vessel Disease: Post-Radiation Encephalopathy.International journal of molecular sciences · 2020Review
- Neurocognitive Decline Following Radiotherapy: Mechanisms and Therapeutic Implications.Cancers · 2020Review
- Article
- Particle Radiation Induced Neurotoxicity in the Central Nervous System.International journal of particle therapy · 2018Review
- Role of NADPH oxidase in radiation-induced pro-oxidative and pro-inflammatory pathways in mouse brain.International journal of radiation biology · 2017Article
- Corilagin Attenuates Radiation-Induced Brain Injury in Mice.Molecular neurobiology · 2016Article
- Article
- Electroacupuncture prevents cognitive impairments by regulating the early changes after brain irradiation in rats.PloS one · 2015Article
- Treatment of brain metastases in lung cancer: strategies to avoid/reduce late complications of whole brain radiation therapy.Current treatment options in oncology · 2013Review
- Telmisartan attenuates hepatic fibrosis in bile duct-ligated rats.Acta pharmacologica Sinica · 2012Article
- Whole brain radiation-induced cognitive impairment: pathophysiological mechanisms and therapeutic targets.Biomolecules & therapeutics · 2012Review
- Radiation attenuates physiological angiogenesis by differential expression of VEGF, Ang-1, tie-2 and Ang-2 in rat brain.Radiation research · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Blockers of the renin-angiotensin-aldosterone system (RAAS) ameliorate cognitive deficits and some aspects of brain injury after whole-brain irradiation. We investigated whether treatment with the angiotensin II type 1 receptor antagonist L-158,809 at a dose that protects cognitive function after fractionated whole-brain irradiation reduced radiation-induced neuroinflammation and changes in hippocampal neurogenesis, well-characterized effects that are associated with radiation-induced brain injury. Male F344 rats received L-158,809 before, during and after a single 10-Gy dose of radiation. Expression of cytokines, angiotensin II receptors and angiotensin-converting enzyme 2 was evaluated by real-time PCR 24 h, 1 week and 12 weeks after irradiation. At the latter times, microglial density and proliferating and activated microglia were analyzed in the dentate gyrus of the hippocampus. Cell proliferation and neurogenesis were also quantified in the dentate subgranular zone. L-158,809 treatment modestly increased mRNA expression for Ang II receptors and TNF-α but had no effect on radiation-induced effects on hippocampal microglia or neurogenesis. Thus, although L-158,809 ameliorates cognitive deficits after whole-brain irradiation, the drug did not mitigate the neuroinflammatory microglial response or rescue neurogenesis. Additional studies are required to elucidate other mechanisms of normal tissue injury that may be modulated by RAAS blockers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.