ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011
Skeletal muscle fat content is inversely associated with bone strength in young girls.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 71 citations in OpenAlex.
- Effects of a Randomized Weight Loss Intervention Trial in Obese Adolescents on Tibia and Radius Bone Geometry and Volumetric Density.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Trial
- Smaller and thinner long bones in children and adolescents with cerebral palsy and other neuromotor impairments.Frontiers in endocrinology · 2025Article
- Improving the identification of bone-specific physical activity using wrist-worn accelerometry: A cross-sectional study in 11-12-year-old Australian children.European journal of sport science · 2024Article
- Precision Errors and Monitoring Time Interval in Pediatric Muscle Imaging and Neuromuscular Performance Assessment.Journal of musculoskeletal & neuronal interactions · 2024Article
- Predictors of visceral and subcutaneous adipose tissue and muscle density: The ShapeUp! Kids study.Nutrition, metabolism, and cardiovascular diseases : NMCD · 2024Article
- Review
- Prospective Analysis of Muscle Adiposity in Children With X-linked Hypophosphatemic Rickets vs Control Children.Journal of the Endocrine Society · 2022Article
- Sex-Specific Changes in Physical Risk Factors for Anterior Cruciate Ligament Injury by Chronological Age and Stages of Growth and Maturation From 8 to 18 Years of Age.Journal of athletic training · 2022Article
- Density and Fat Fraction of the Psoas, Paraspinal, and Oblique Muscle Groups Are Associated With Lumbar Vertebral Bone Mineral Density in a Multi-Ethnic Community-Living Population: The Multi-Ethnic Study of Atherosclerosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Circulating Fibroblast Growth Factor-21 Levels in Rheumatoid Arthritis: Associations With Disease Characteristics, Body Composition, and Physical Functioning.The Journal of rheumatology · 2021Article
- Association of Low Muscle Density With Deteriorations in Muscle Strength and Physical Functioning in Rheumatoid Arthritis.Arthritis care & research · 2021Article
- Intramuscular Fat Accumulation and Associations With Body Composition, Strength, and Physical Functioning in Patients With Rheumatoid Arthritis.Arthritis care & research · 2018Observational
- Postural control is associated with muscle power in post-menopausal women with low bone mass.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Article
- Fat and bone in children - where are we now?Annals of pediatric endocrinology & metabolism · 2018Article
- Muscle Deficits in Rheumatoid Arthritis Contribute to Inferior Cortical Bone Structure and Trabecular Bone Mineral Density.The Journal of rheumatology · 2017Article
- Muscle-Bone Interactions in Pediatric Bone Diseases.Current osteoporosis reports · 2017Review
- Bone Density in the Obese Child: Clinical Considerations and Diagnostic Challenges.Calcified tissue international · 2017Article
- Longitudinal bone, muscle and adipose tissue changes in physically active subjects - sex differences during adolescence and maturity.Journal of musculoskeletal & neuronal interactions · 2016Article
- Adverse Fat Depots and Marrow Adiposity Are Associated With Skeletal Deficits and Insulin Resistance in Long-Term Survivors of Pediatric Hematopoietic Stem Cell Transplantation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2015Observational
- Tibia and radius bone geometry and volumetric density in obese compared to non-obese adolescents.Bone · 2015Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Childhood obesity is an established risk factor for metabolic disease. The influence of obesity on bone development, however, remains controversial and may depend on the pattern of regional fat deposition. Therefore, we examined the associations of regional fat compartments of the calf and thigh with weight-bearing bone parameters in girls. Data from 444 girls aged 9 to 12 years from the Jump-In: Building Better Bones study were analyzed. Peripheral quantitative computed tomography (pQCT) was used to assess bone parameters at metaphyseal and diaphyseal sites of the femur and tibia along with subcutaneous adipose tissue (SAT, mm(2) ) and muscle density (mg/cm(3) ), an index of skeletal muscle fat content. As expected, SAT was positively correlated with total-body fat mass (r = 0.87-0.89, p < .001), and muscle density was inversely correlated with total-body fat mass (r = -0.24 to -0.28, p < .001). Multiple linear regression analyses with SAT, muscle density, muscle cross-sectional area, bone length, maturity, and ethnicity as independent variables showed significant associations between muscle density and indices of bone strength at metaphyseal (β = 0.13-0.19, p < .001) and diaphyseal (β = 0.06-0.09, p < .01) regions of the femur and tibia. Associations between SAT and indices of bone strength were nonsignificant at all skeletal sites (β = 0.03-0.05, p > .05), except the distal tibia (β = 0.09, p = .03). In conclusion, skeletal muscle fat content of the calf and thigh is inversely associated with weight-bearing bone strength in young girls.
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Registered trials
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