ArticleInternational journal of cancer2012
Body fat distribution, weight change during adulthood, and thyroid cancer risk in the NIH-AARP Diet and Health Study.
Article in International journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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29 citing papers in PubMed, 66 citations in OpenAlex.
- The association between selenium and other micronutrients and thyroid cancer incidence in the NIH-AARP Diet and Health Study.PloS one · 2014Trial
- Spatial concordance patterns of breast and thyroid cancer based on burden inequalities and related risk factors analyses.Gland surgery · 2026Article
- Obesity and thyroid cancer: mechanisms and clinical implications.Frontiers in nutrition · 2026Review
- Investigating papillary thyroid cancer risk factors among women living at the central region of Iran: a case-control study.BMC endocrine disorders · 2025Article
- Thyroid Cancer and Physical Activity: A Bibliometric Analysis.Journal of multidisciplinary healthcare · 2025Review
- Metabolic obesity phenotypes and thyroid cancer risk: A systematic exploration of the evidence.Obesity science & practice · 2024Review
- Obesity and thyroid cancer: unraveling the connection through a systematic review and meta-analysis of cohort studies.Journal of diabetes and metabolic disorders · 2024Review
- Article
- Anthropometric, dietary, and lifestyle factors and risk of advanced thyroid cancer: The NIH-AARP diet and health cohort study.Clinical endocrinology · 2023Article
- Metabolic syndrome and thyroid Cancer: risk, prognosis, and mechanism.Discover oncology · 2023Review
- Links between Breast and Thyroid Cancer: Hormones, Genetic Susceptibility and Medical Interventions.Cancers · 2022Review
- Association between Obesity Indexes and Thyroid Cancer Risk in Korean Women: Nested Case-Control Study.Cancers · 2022Article
- A longitudinal examination of objective neighborhood walkability, body mass index, and waist circumference: the REasons for Geographic And Racial Differences in Stroke study.The international journal of behavioral nutrition and physical activity · 2022Article
- Risk Factors for Anaplastic Thyroid Carcinoma: A Case Series From a Tertiary Referral Center for Thyroid Surgery and Literature Analysis.Frontiers in oncology · 2022Article
- Effects of concomitant obesity and diabetes on the aggressiveness and outcomes of differentiated thyroid cancer patients.Archives of endocrinology and metabolism · 2021Article
- A multicenter, prospective study to observe the initial management of patients with differentiated thyroid cancer in China (DTCC study).BMC endocrine disorders · 2021Article
- Association of thyroid cancer risk with plasma 25-hydroxyvitamin D and vitamin D binding protein: a case-control study in China.Journal of endocrinological investigation · 2020Article
- Anthropometric measures of body fat and obesity-related cancer risk: sex-specific differences in Framingham Offspring Study adults.International journal of obesity (2005) · 2020Article
- Do traditional BMI categories capture future obesity? A comparison with trajectories of BMI and incidence of cancer.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2020Article
- Adiposity and the risk of thyroid nodules with a high-suspicion sonographic pattern: a large cross-sectional epidemiological study.Journal of thoracic disease · 2019Article
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Authors and funding
6 authors at 4 institutions in 1 country.
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Abstract
Body mass index (BMI) has been positively associated with thyroid cancer risk in several studies, but the underlying mechanisms remain unclear. We examined the associations for waist and hip circumference and weight change during adulthood with thyroid cancer risk among 125,347 men and 72,363 women in the NIH-AARP Diet and Health Study who completed a second mailed questionnaire in 1996-1997. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated separately by sex and adjusted for race/ethnicity, education and smoking status. During follow-up (median = 10.1 years), 106 men and 105 women were diagnosed with a first primary thyroid cancer, as identified through linkage to state cancer registries. Having a large waist circumference (above the clinical cutpoint for normal: > 102 cm in men and > 88 cm in women) was associated with increased risk in both men (HR = 1.79, 95% CI: 1.21-2.63) and women (HR = 1.54, 95% CI: 1.05-2.26). Having both a large waist and BMI in the obese range (≥ 30 kg/m2) approximately doubled the risk of thyroid cancer (HR in men = 2.13, 95% CI: 1.18-3.85; HR in women = 1.91, 95% CI: 1.31-3.25) compared to having a normal waist circumference/normal BMI (18.5-24.9 kg/m2). We also observed positive association for weight gain between ages 18-35 in men (gained ≥ 10.0 kg vs. lost/gained < 5 kg, HR = 1.49, 95% CI: 0.93-2.39, p-trend = 0.03), but the association was less pronounced in women. No clear association for weight gain in later life was observed. These results support a potential role for hormonal and metabolic parameters common to central adiposity in thyroid carcinogenesis.
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