ReviewCurrent genetics2011
Gene fragmentation: a key to mitochondrial genome evolution in Euglenozoa?
Review in Current genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 47 citations in OpenAlex.
- The Constructive Neutral Evolution of Behaviour.Ecology and evolution · 2025Article
- Hydrophobicity-Driven Increases in Editing in Mitochondrial mRNAs during the Evolution of Kinetoplastids.Molecular biology and evolution · 2023Article
- Guide RNA Repertoires in the Main Lineages ofFrontiers in cellular and infection microbiology · 2021Article
- A Uniquely Complex Mitochondrial Proteome from Euglena gracilis.Molecular biology and evolution · 2020Article
- Gene fragmentation and RNA editing without borders: eccentric mitochondrial genomes of diplonemids.Nucleic acids research · 2020Article
- Article
- A single-cell genome reveals diplonemid-like ancestry of kinetoplastid mitochondrial gene structure.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Article
- Trypanosomatid mitochondrial RNA editing: dramatically complex transcript repertoires revealed with a dedicated mapping tool.Nucleic acids research · 2018Article
- Mitochondrial Genome Evolution and a Novel RNA Editing System in Deep-Branching Heteroloboseids.Genome biology and evolution · 2017Article
- Post-transcriptional mending of gene sequences: Looking under the hood of mitochondrial gene expression in diplonemids.RNA biology · 2016Review
- Hyper-eccentric structural genes in the mitochondrial genome of the algal parasite Hemistasia phaeocysticola.Genome biology and evolution · 2016Article
- From simple to supercomplex: mitochondrial genomes of euglenozoan protists.F1000Research · 2016Review
- Unexpectedly Streamlined Mitochondrial Genome of the Euglenozoan Euglena gracilis.Genome biology and evolution · 2015Article
- Genome mining offers a new starting point for parasitology research.Parasitology research · 2015Review
- Missing genes, multiple ORFs, and C-to-U type RNA editing in Acrasis kona (Heterolobosea, Excavata) mitochondrial DNA.Genome biology and evolution · 2014Article
- Selective forces for the origin of spliceosomes.Journal of molecular evolution · 2012Article
- Complete mitochondrial genomes of two cockroaches, Blattella germanica and Periplaneta americana, and the phylogenetic position of termites.Current genetics · 2012Article
- The falsifiability of the models for the origin of eukaryotes.Current genetics · 2011Review
- Stunning Intricacies of RNA Editing Complexes RECC, RESC, and REH2C: Functional Organization, Developmental Regulation, and Evolutionary History in Kinetoplastid Protists.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phylum Euglenozoa comprises three groups of eukaryotic microbes (kinetoplastids, diplonemids, and euglenids), the mitochondrial (mt) genomes of which exhibit radically different modes of organization and expression. Gene fragmentation is a striking feature of both euglenid and diplonemid mtDNAs. To rationalize the emergence of these highly divergent mtDNA types and the existence of insertion/deletion RNA editing (in kinetoplastids) and trans-splicing (in diplonemids), we propose that in the mitochondrion of the common evolutionary ancestor of Euglenozoa, small expressed gene fragments promoted a rampant neutral evolutionary pathway. Interactions between small antisense transcripts of these gene fragments and full-length transcripts, assisted by RNA-processing enzymes, permitted the emergence of RNA editing and/or trans-splicing activities, allowing the system to tolerate indel mutations and further gene fragmentation, respectively, and leading to accumulation of additional mutations. In this way, dramatically different mitochondrial genome structures and RNA-processing machineries were able to evolve. The paradigm of constructive neutral evolution acting on the widely different mitochondrial genetic systems in Euglenozoa posits the accretion of initially neutral molecular interactions by genetic drift, leading inevitably to the observed 'irremediable complexity'.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.