ArticleJournal of molecular histology2011
Increased expression of transcription initiation factor IIB after rat traumatic brain injury.
Article in Journal of molecular histology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Transcriptional and Translational Regulation of Differentially Expressed Genes in Yucatan Miniswine Brain Tissues following Traumatic Brain Injury.Journal of bioinformatics and systems biology : Open access · 2024Article
- Viral targeting of TFIIB impairs de novo polymerase II recruitment and affects antiviral immunity.PLoS pathogens · 2018Article
- Increased Expression of TBP/TFIID after spinal cord injury in adult rats.Cellular and molecular neurobiology · 2014Article
- A new paradigm for transcription factor TFIIB functionality.Scientific reports · 2014Article
- The expression patterns of Septin-9 after traumatic brain injury in rat brain.Journal of molecular neuroscience : MN · 2013Article
- Müller glia cells activation in rat retina after optic nerve injury: spatiotemporal correlation with transcription initiation factor IIb.Journal of molecular neuroscience : MN · 2013Article
- SCY1-like 1 binding protein 1 (SCYL1-bp1) interacts with p53-induced RING H2 protein (Pirh2) after traumatic brain injury in rats.Journal of molecular histology · 2013Article
- Phosphorylated retinoblastoma protein (p-Rb) is involved in neuronal apoptosis after traumatic brain injury in adult rats.Journal of molecular histology · 2013Article
- General transcription factor IIb overexpression and a potential link to proliferation in human hepatocellular carcinoma.Pathology oncology research : POR · 2013Article
- Transcription initiation factor IIB involves in Schwann cell differentiation after rat sciatic nerve crush.Journal of molecular neuroscience : MN · 2013Article
- Involvement of transcription initiation factor IIB in the light-induced death of rat retinal ganglion cells in vivo.Journal of molecular histology · 2013Article
- Temporal and spatial expression of KIF3B after acute spinal cord injury in adult rats.Journal of molecular neuroscience : MN · 2013Article
- Up-regulation of ski-interacting protein in rat brain cortex after traumatic brain injury.Journal of molecular histology · 2013Article
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Authors and funding
10 authors.
Funding
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Abstract
The protein TFIIB is a general transcription initiation factor that plays a pivotal role in the preinitiation complex (PIC) and selects the transcription initiation site. However, its distribution and function in the central nervous system (CNS) remains unclear. In the present study, we mainly investigated the expression and cellular localization of TFIIB during traumatic brain injury (TBI). Western blot analysis revealed that TFIIB was present in normal rat brain cortex. It gradually increased, reached a peak at the 5th day after TBI, and then decreased. Importantly, more TFIIB was colocalized with astrocytes and microglia, which are largely proliferated. In addition, Western blot detection showed that the 5th day post injury was also the proliferation peak indicated by the elevated expression of PCNA. Importantly, injury-induced expression of TFIIB was colabelled by proliferating cell nuclear antigen (proliferating cells marker). These data suggested that TFIIB may be implicated in the proliferation of astrocytes and microglia and the recovery of neurological outcomes. But the inherent mechanisms remained unknown. Further studies are needed to confirm the exact role of TFIIB after brain injury.
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