ArticleHuman genetics2011
The X-inactivation trans-activator Rnf12 is negatively regulated by pluripotency factors in embryonic stem cells.
Article in Human genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 54 citations in OpenAlex.
- Multiscale chromatin modeling of chromosome X structural changes upon inactivation highlights the differential regulatory mechanism ofbioRxiv : the preprint server for biology · 2026Article
- The interferon γ pathway enhances pluripotency and X-chromosome reactivation in iPSC reprogramming.Science advances · 2024Article
- Orchestrating Asymmetric Expression: Mechanisms behindEpigenomes · 2024Review
- The compleX balancing act of controlling X-chromosome dosage and how it impacts mammalian germline development.The Biochemical journal · 2023Article
- Cohesin controls X chromosome structure remodeling and X-reactivation during mouse iPSC-reprogramming.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A long noncoding RNA influences the choice of the X chromosome to be inactivated.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- The Molecular and Nuclear Dynamics of X-Chromosome Inactivation.Cold Spring Harbor perspectives in biology · 2022Review
- A NovelMolecular and cellular biology · 2021Article
- Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation.Nature communications · 2021Article
- Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal.FEBS letters · 2021Article
- Pathogenic variants in E3 ubiquitin ligase RLIM/RNF12 lead to a syndromic X-linked intellectual disability and behavior disorder.Molecular psychiatry · 2019Article
- Exit from Naive Pluripotency Induces a Transient X Chromosome Inactivation-like State in Males.Cell stem cell · 2018Article
- RNF12 X-Linked Intellectual Disability Mutations Disrupt E3 Ligase Activity and Neural Differentiation.Cell reports · 2018Article
- Xist and Tsix Transcription Dynamics Is Regulated by the X-to-Autosome Ratio and Semistable Transcriptional States.Molecular and cellular biology · 2016Article
- Impaired imprinted X chromosome inactivation is responsible for the skewed sex ratio following in vitro fertilization.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cis- and trans-regulation in X inactivation.Chromosoma · 2016Review
- Dynamic interplay and function of multiple noncoding genes governing X chromosome inactivation.Biochimica et biophysica acta · 2016Review
- Overexpression of OCT4A ortholog elevates endogenous XIST in porcine parthenogenic blastocysts.The Journal of reproduction and development · 2015Article
- A prominent and conserved role for YY1 in Xist transcriptional activation.Nature communications · 2014Article
- X Chromosome of female cells shows dynamic changes in status during human somatic cell reprogramming.Stem cell reports · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
X-inactivation, the molecular mechanism enabling dosage compensation in mammals, is tightly controlled during mouse early embryogenesis. In the morula, X-inactivation is imprinted with exclusive silencing of the paternally inherited X-chromosome. In contrast, in the post-implantation epiblast, X-inactivation affects randomly either the paternal or the maternal X-chromosome. The transition from imprinted to random X-inactivation takes place in the inner cell mass (ICM) of the blastocyst from which embryonic stem (ES) cells are derived. The trigger of X-inactivation, Xist, is specifically downregulated in the pluripotent cells of the ICM, thereby ensuring the reactivation of the inactive paternal X-chromosome and the transient presence of two active X-chromosomes. Moreover, Tsix, a critical cis-repressor of Xist, is upregulated in the ICM and in ES cells where it imposes a particular chromatin state at the Xist promoter that ensures the establishment of random X-inactivation upon differentiation. Recently, we have shown that key transcription factors supporting pluripotency directly repress Xist and activate Tsix and thus couple Xist/Tsix control to pluripotency. In this manuscript, we report that Rnf12, a third X-linked gene critical for the regulation of X-inactivation, is under the control of Nanog, Oct4 and Sox2, the three factors lying at the heart of the pluripotency network. We conclude that in mouse ES cells the pluripotency-associated machinery exerts an exhaustive control of X-inactivation by taking over the regulation of all three major regulators of X-inactivation: Xist, Tsix, and Rnf12.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.