ReviewCellular and molecular life sciences : CMLS2011
The multiple roles of Notch signaling during left-right patterning.
Review in Cellular and molecular life sciences : CMLS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- The notochord: development, disease and stem cell-based modelling.Development (Cambridge, England) · 2026Review
- Understanding normal cardiac morphogenesis and its disruptions: a journey through pathways.Frontiers in genetics · 2026Review
- Polarity Establishment and Maintenance in Ascidian Notochord.Frontiers in cell and developmental biology · 2020Review
- The Role of Cerl2 in the Establishment of Left-Right Asymmetries during Axis Formation and Heart Development.Journal of cardiovascular development and disease · 2017Review
- The Caenorhabditis elegans Excretory System: A Model for Tubulogenesis, Cell Fate Specification, and Plasticity.Genetics · 2016Review
- Xenopus as a model organism for birth defects-Congenital heart disease and heterotaxy.Seminars in cell & developmental biology · 2016Review
- DNA Methylation of PITX2 and PANCR Is Prognostic for Overall Survival in Patients with Resected Adenocarcinomas of the Biliary Tract.PloS one · 2016Article
- TGF-β Signaling Regulates the Differentiation of Motile Cilia.Cell reports · 2015Article
- Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.Cell research · 2014Article
- A potential molecular pathogenesis of cardiac/laterality defects in Oculo-Facio-Cardio-Dental syndrome.Developmental biology · 2014Article
- The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality.Nature · 2013Article
- Phenotypic and functional consequences of haploinsufficiency of genes from exocyst and retinoic acid pathway due to a recurrent microdeletion of 2p13.2.Orphanet journal of rare diseases · 2013Article
- Development and clinical validation of a real-time PCR assay for PITX2 DNA methylation to predict prostate-specific antigen recurrence in prostate cancer patients following radical prostatectomy.The Journal of molecular diagnostics : JMD · 2013Article
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Authors and funding
1 author.
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Abstract
The establishment of left-right (LR) asymmetry is regulated by intricate signaling mechanisms during embryogenesis and this asymmetry is critical for morphogenesis as well as the positioning of internal organs within the organism. Recent progress including elucidation of ion transporters, leftward nodal flow, and regulation of asymmetric gene expression contributes to our understanding of how the breaking of the symmetry is initiated and how this laterality information is subsequently transmitted to the organ primordium. A number of developmental signaling pathways have been implicated in this complex process. In this review, we will focus on the roles of the Notch signaling pathway during development of LR asymmetry. The Notch signaling pathway is a short-range communication system between neighboring cells. While Notch signaling plays essential roles in regulating the morphogenesis of the node and left-specific expression of Nodal in the lateral plate mesoderm, a hallmark gene in LR patterning, Notch signaling also suppresses the expression of Pitx2 that is a direct downstream target of Nodal during later stages of development. This negative activity of Notch signaling towards left-specific activity was recently shown to be inhibited by the B cell lymphoma 6 (BCL6)/BCL6 co-repressor (BcoR) transcriptional repressor complex in a target-specific manner. The complex regulation of Notch-dependent gene expression for LR asymmetry will be highlighted in this review.
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