ArticleCardiovascular drugs and therapy2011
Reduction of myocardial infarct size by dronedarone in pigs--a pleiotropic action?
Article in Cardiovascular drugs and therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- No robust reduction of infarct size and no-reflow by metoprolol pretreatment in adult Göttingen minipigs.Basic research in cardiology · 2023Article
- Interaction of Cardiovascular Nonmodifiable Risk Factors, Comorbidities and Comedications With Ischemia/Reperfusion Injury and Cardioprotection by Pharmacological Treatments and Ischemic Conditioning.Pharmacological reviews · 2023Review
- Signaling Pathways Involved in Myocardial Ischemia-Reperfusion Injury and Cardioprotection: A Systematic Review of Transcriptomic Studies inJournal of cardiovascular development and disease · 2022Review
- Effect of DrOnedarone on atrial fibrosis progression and atrial fibrillation recurrence postablation: Design of the EDORA randomized clinical trial.Journal of cardiovascular electrophysiology · 2021Article
- Integration of "omics" techniques: Dronedarone affects cardiac remodeling in the infarction border zone.Experimental biology and medicine (Maywood, N.J.) · 2018Article
- Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation.Clinical Medicine Insights. Cardiology · 2013Article
- Dronedarone prevents microcirculatory abnormalities in the left ventricle during atrial tachypacing in pigs.British journal of pharmacology · 2012Article
- Oxidative Stress and Microcirculatory Flow Abnormalities in the Ventricles during Atrial Fibrillation.Frontiers in physiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDronedarone is a first-line drug to prevent the recurrence of atrial fibrillation according to ESC guidelines. In the recent ATHENA trial, dronedarone reduced mortality and also hospitalization for acute coronary syndrome in patients with atrial fibrillation. This beneficial effect suggests that dronedarone might have also an impact on events associated with ischemia/reperfusion injury.
methodsFourteen anesthetized pigs received either dronedarone (2.5 mg/kg) or placebo. Effects of dronedarone on heart rate and blood pressure were reversed by atrial pacing and aortic constriction before pigs were subjected to 90 min regional low-flow myocardial ischemia and 2 h reperfusion. Regional myocardial blood flow was measured with microspheres and infarct size determined by TTC staining.
resultsWith comparable heart rate and left ventricular pressure during ischemia, dronedarone reduced infarct size from 34 ± 3% to 22 ± 4% (p < 0.05) of the area at risk. Subendocardial blood flow during ischemia was not different between groups. The relationship between ischemic subendocardial blood flow in the area at risk and infarct size was displaced downwards, reflecting a direct cardioprotective action of dronedarone.
conclusionThe beneficial effect of dronedarone is attributed to cardioprotective properties, possibly through attenuation of calcium overload during myocardial ischemia/reperfusion.
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