ReviewSensors (Basel, Switzerland)2011
Physiological sensing of carbon dioxide/bicarbonate/pH via cyclic nucleotide signaling.
Review in Sensors (Basel, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- A Novel Strategy for Highly Efficient Heterologous Expression of Carbonic Anhydrase inInternational journal of molecular sciences · 2026Article
- Wireless Soft Athlete Bioelectronics for Monitoring Carbon Dioxide Ventilation and Physiological Performance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Scaffold Hopping and Optimization of Small Molecule Soluble Adenyl Cyclase Inhibitors Led by Free Energy Perturbation.Journal of chemical information and modeling · 2023Article
- Potent antifungal properties of gallic acid inBiotechnologia · 2023Article
- Chemoproteomic identification of CONature chemical biology · 2022Article
- A Highlight on the Inhibition of Fungal Carbonic Anhydrases as Drug Targets for the Antifungal Armamentarium.International journal of molecular sciences · 2021Review
- Carbon dioxide-dependent signal transduction in mammalian systems.Interface focus · 2021Review
- In vivo measurement of pH and COScientific reports · 2021Article
- Physiological responses of Saccharomyces cerevisiae to industrially relevant conditions: Slow growth, low pH, and high COBiotechnology and bioengineering · 2020Article
- An interplay of structure and intrinsic disorder in the functionality of peptidylarginine deiminases, a family of key autoimmunity-related enzymes.Cellular and molecular life sciences : CMLS · 2019Review
- Pharmacological modulation of the COPharmacology & therapeutics · 2018Review
- Perspective on Protein Arginine Deiminase Activity-Bicarbonate Is a pH-Independent Regulator of Citrullination.Frontiers in immunology · 2018Article
- Proton Transport Chains in Glucose Metabolism: Mind the Proton.Frontiers in neuroscience · 2018Review
- COAmerican journal of respiratory cell and molecular biology · 2017Article
- Evidence for Rapid Oxidative Phosphorylation and Lactate Fermentation in Motile Human Sperm by HyperpolarizedScientific reports · 2017Article
- Proton Fall or Bicarbonate Rise: GLYCOLYTIC RATE IN MOUSE ASTROCYTES IS PAVED BY INTRACELLULAR ALKALINIZATION.The Journal of biological chemistry · 2016Article
- Transmembrane transporter expression regulated by the glucosylceramide pathway in Cryptococcus neoformans.BMC research notes · 2015Article
- Extracellular hemoglobin: the case of a friend turned foe.Frontiers in physiology · 2015Review
- Soluble adenylyl cyclase in the eye.Biochimica et biophysica acta · 2014Review
- Carbon dioxide-sensing in organisms and its implications for human disease.Cellular and molecular life sciences : CMLS · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Carbon dioxide (CO(2)) is produced by living organisms as a byproduct of metabolism. In physiological systems, CO(2) is unequivocally linked with bicarbonate (HCO(3)(-)) and pH via a ubiquitous family of carbonic anhydrases, and numerous biological processes are dependent upon a mechanism for sensing the level of CO(2), HCO(3), and/or pH. The discovery that soluble adenylyl cyclase (sAC) is directly regulated by bicarbonate provided a link between CO(2)/HCO(3)/pH chemosensing and signaling via the widely used second messenger cyclic AMP. This review summarizes the evidence that bicarbonate-regulated sAC, and additional, subsequently identified bicarbonate-regulate nucleotidyl cyclases, function as evolutionarily conserved CO(2)/HCO(3)/pH chemosensors in a wide variety of physiological systems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.