ArticlePloS one2011
Thyroid disruption by Di-n-butyl phthalate (DBP) and mono-n-butyl phthalate (MBP) in Xenopus laevis.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- First Identification of a Large Set of Serine Hydrolases by Activity-Based Protein Profiling in Dibutyl Phthalate-Exposed Zebrafish Larvae.International journal of molecular sciences · 2022Article
- Amphibian Metamorphosis Assay: Investigation of the potential effects of five chemicals on the hypothalamic-pituitary thyroid axis of Xenopus laevis.Regulatory toxicology and pharmacology : RTP · 2022Article
- Plasticizers: negative impacts on the thyroid hormone system.Environmental science and pollution research international · 2022Review
- Biomarkers of Exposure to Phthalate Mixtures and Adverse Birth Outcomes in a Puerto Rico Birth Cohort.Environmental health perspectives · 2022Article
- Gestational Phthalate Exposure and Preschool Attention Deficit Hyperactivity Disorder in Norway.Environmental epidemiology (Philadelphia, Pa.) · 2021Article
- Prenatal Phthalates Exposure and Cord Thyroid Hormones: A Birth Cohort Study in Southern Taiwan.International journal of environmental research and public health · 2021Article
- Effects of Subacute Exposure of Dibutyl Phthalate on the Homeostatic Model Assessment, Thyroid Function, and Redox Status in Rats.BioMed research international · 2021Article
- Associations of Phthalates and Phthalate Replacements With CRH and Other Hormones Among Pregnant Women in Puerto Rico.Journal of the Endocrine Society · 2019Article
- Contaminant and Environmental Influences on Thyroid Hormone Action in Amphibian Metamorphosis.Frontiers in endocrinology · 2019Review
- Effects of Gender on the Association of Urinary Phthalate Metabolites with Thyroid Hormones in Children: A Prospective Cohort Study in Taiwan.International journal of environmental research and public health · 2017Article
- Early Phthalates Exposure in Pregnant Women Is Associated with Alteration of Thyroid Hormones.PloS one · 2016Article
- Vimentin-Mediated Steroidogenesis Induced by Phthalate Esters: Involvement of DNA Demethylation and Nuclear Factor κB.PloS one · 2016Article
- Identification of Drosophila-based endpoints for the assessment and understanding of xenobiotic-mediated male reproductive adversities.Toxicological sciences : an official journal of the Society of Toxicology · 2014Article
- Urinary phthalate metabolites are associated with body mass index and waist circumference in Chinese school children.PloS one · 2013Article
- Designing Endocrine Disruption Out of the Next Generation of Chemicals.Green chemistry : an international journal and green chemistry resource : GC · 2013Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDi-n-butyl phthalate (DBP), a chemical widely used in many consumer products, is estrogenic and capable of producing seriously reproductive and developmental effects in laboratory animals. However, recent in vitro studies have shown that DBP and mono-n-butyl phthalate (MBP), the major metabolite of DBP, possessed thyroid hormone receptor (TR) antagonist activity. It is therefore important to consider DBP and MBP that may interfere with thyroid hormone system. METHODOLOGY/PRINCIPAL
findingsNieuwkoop and Faber stage 51 Xenopus laevis were exposed to DBP and MBP (2, 10 or 15 mg/L) separately for 21 days. The two test chemicals decelerated spontaneous metamorphosis in X. laevis at concentrations of 10 and 15 mg/L. Moreover, MBP seemed to possess stronger activity. The effects of DBP and MBP on inducing changes of expression of selected thyroid hormone response genes: thyroid hormone receptor-beta (TRβ), retinoid X receptor gamma (RXRγ), alpha and beta subunits of thyroid-stimulating hormone (TSHα and TSHβ) were detected by qPCR at all concentrations of the compounds. Using mammalian two-hybrid assay in vitro, we found that DBP and MBP enhanced the interactions between co-repressor SMRT (silencing mediator for retinoid and thyroid hormone receptors) and TR in a dose-dependent manner, and MBP displayed more markedly. In addition, MBP at low concentrations (2 and 10 mg/L) caused aberrant methylation of TRβ in head tissue.
conclusionsThe current findings highlight potential disruption of thyroid signalling by DBP and MBP and provide data for human risk assessment.
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