ArticleJournal of human hypertension2011
Non-dipping pattern relates to endothelial dysfunction in patients with uncontrolled resistant hypertension.
Article in Journal of human hypertension, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association.Hypertension (Dallas, Tex. : 1979) · 2018Guideline
- Evening dosing of antihypertensive therapy to reduce cardiovascular events: a third type of evidence based on a systematic review and meta-analysis of randomized trials.Journal of clinical hypertension (Greenwich, Conn.) · 2014Pooled it
- EASIX and Arterial stiffness in relation to nocturnal blood pressure patterns in newly diagnosed hypertension.Journal of human hypertension · 2026Article
- Non-Dipping Pattern Is Associated with Periprocedural Myocardial Infarction in Hypertensive Patients Undergoing Elective Percutaneous Coronary Intervention.Medicina (Kaunas, Lithuania) · 2025Observational
- Blood pressure variability in CKD patients with and without nocturnal hypertension.Journal of human hypertension · 2025Article
- The Influence of Non-Dipping Pattern of Blood Pressure in Gestational Hypertension on Early Onset of Hypertension Later in Life-Single Center Experience in Very-High-Risk Southeast and Central European Country.International journal of molecular sciences · 2024Article
- Acute Effect of Night Shift Work on Endothelial Function with and without Naps: A Scoping Review.International journal of environmental research and public health · 2023Article
- Short-term blood pressure variability as a potential therapeutic target for kidney disease.Clinical hypertension · 2023Review
- Acute renal denervation normalizes aortic function and decreases blood pressure in spontaneously hypertensive rats.Scientific reports · 2020Article
- Echocardiographic strain analysis reflects impaired ventricular function in youth with pediatric-onset systemic lupus erythematosus.Echocardiography (Mount Kisco, N.Y.) · 2020Article
- Nocturnal blood pressure is associated with sympathetic nerve activity in patients with chronic kidney disease.Physiological reports · 2020Article
- Blood pressure variability: its relevance for cardiovascular homeostasis and cardiovascular diseases.Hypertension research : official journal of the Japanese Society of Hypertension · 2020Review
- Nocturnal blood pressure dipping as a marker of endothelial function and subclinical atherosclerosis in pediatric-onset systemic lupus erythematosus.Arthritis research & therapy · 2020Article
- Plasma xanthine oxidase activity is related to increased sodium and left ventricular hypertrophy in resistant hypertension.Free radical biology & medicine · 2019Article
- Impaired nocturnal blood pressure dipping in patients with type 2 diabetes mellitus.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Controlled Versus Uncontrolled Resistant Hypertension: Are They in the Same Bag?Current hypertension reports · 2018Review
- Ambulatory Blood Pressure in Chronic Kidney Disease: Ready for Prime Time?Kidney international reports · 2016Article
- Improvement in All-Cause Mortality With Blood Pressure Control in a Group of US Veterans With Drug-Resistant Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Blood pressure variability: assessment, predictive value, and potential as a therapeutic target.Current hypertension reports · 2015Review
- Non-interventional management of resistant hypertension.World journal of cardiology · 2014Review
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistant hypertension (RHTN) includes both patients whose blood pressure (BP) is uncontrolled on three or more medications (uncontrolled RHTN (UCRH)) and patients whose BP is controlled with use of four or more drugs (controlled RHTN (CRH)). It is unknown whether endothelial function and nocturnal drop demonstrate a similar pattern in patients with CRH and UCRH. We examined circadian BP patterns and vascular function in these patients. In all, 40 CRH and 26 UCRH patients, and 25 normotensives underwent biochemical testing, ambulatory BP monitoring, determination of brachial artery responses to endothelial-dependent (flow-mediated; dilation (FMD)) and independent (nitroglycerin mediated) stimuli. The nighttime drop in systolic BP (SBP) and diastolic BP (DBP) was less pronounced in UCRH than in CRH (SBP, 1.9±1.6 versus 4.9±1.7%; DBP, 7.5±1.8 versus 10.9±1.8%, UCRH and CRH, respectively; P<0.05). FMD was greater in control group compared with RHTN patients. Patients with UCRH had significantly impaired FMD compared with CRH (5.9±2.3% versus 7.1±5.1%; P<0.0001). Therefore, UCRH patients have less nocturnal dipping and a more impaired endothelial response compared with CRH patients. These findings suggest that important differences among patients with RHTN may allow identify subgroups with increased cardiovascular risk.
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