SynthesisInternational journal of obesity (2005)2012
Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.
Synthesis in International journal of obesity (2005), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Gene-diet interaction effects on BMI levels in the Singapore Chinese population.Nutrition journal · 2018Pooled it
- Replication of 6 obesity genes in a meta-analysis of genome-wide association studies from diverse ancestries.PloS one · 2014Pooled it
- Pooled it
- Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians.Diabetologia · 2012Pooled it
- The landscape of adult obesity in Malaysia: a mapping of evidence and contemporary narrative review.The Lancet regional health. Western Pacific · 2026Review
- Genetic Polymorphisms Associated with Obesity in Southeast Asian Populations: A Systematic Review without Meta-Analysis.The Malaysian journal of medical sciences : MJMS · 2025Review
- Genetic Landscape of Obesity in Children: Research Advances and Prospects.Journal of obesity · 2025Review
- The Possible Roles of Glucosamine-6-Phosphate Deaminases in Ammonium Metabolism in Cancer.International journal of molecular sciences · 2024Review
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- Fine Mapping of theFrontiers in genetics · 2022Article
- Converging vulnerability factors for compulsive food and drug use.Neuropharmacology · 2021Review
- Review
- Omics Approaches in Adipose Tissue and Skeletal Muscle Addressing the Role of Extracellular Matrix in Obesity and Metabolic Dysfunction.International journal of molecular sciences · 2021Review
- Genome-wide association study in almost 195,000 individuals identifies 50 previously unidentified genetic loci for eye color.Science advances · 2021Article
- Article
- Cohort profile: the Singapore diabetic cohort study.BMJ open · 2020Article
- Genetics of Obesity in East Asians.Frontiers in genetics · 2020Review
- Obesity-Related Genetic Variants and Hyperuricemia Risk in Chinese Men.Frontiers in endocrinology · 2019Article
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveRecent genome-wide association studies (GWAS) have identified 38 obesity-associated loci among European populations. However, their contribution to obesity in other ethnicities is largely unknown.
methodsWe utilised five GWAS (N=10 482) from Chinese (three cohorts, including one with type 2 diabetes and another one of children), Malay and Indian ethnic groups from Singapore. Data sets were analysed individually and subsequently in combined meta-analysis for Z-score body-mass index (BMI) associations.
resultsVariants at the FTO locus showed the strongest associations with BMI Z-score after meta-analysis (P-values 1.16 × 10(-7)-7.95 × 10(-7)). We further detected associations with nine other index obesity variants close to the MC4R, GNPDA2, TMEM18, QPCTL/GIPR, BDNF, ETV5, MAP2K5/SKOR1, SEC16B and TNKS/MSRA loci (meta-analysis P-values ranging from 3.58 × 10(-4)-1.44 × 10(-2)). Three other single-nucleotide polymorphisms (SNPs) from CADM2, PTBP2 and FAIM2 were associated with BMI (P-value ≤ 0.0418) in at least one dataset. The neurotrophin/TRK pathway (P-value=0.029) was highlighted by pathway-based analysis of loci that had statistically significant associations among Singaporean populations.
conclusionOur data confirm the role of FTO in obesity predisposition among Chinese, Malays and Indians, the three major Asian ethnic groups. We additionally detected associations for 12 obesity-associated SNPs among Singaporeans. Thus, it is likely that Europeans and Asians share some of the genetic predisposition to obesity. Furthermore, the neurotrophin/TRK signalling may have a central role for common obesity among Asians.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.