Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
The effects of nicotine replacement on cognitive brain activity during smoking withdrawal studied with simultaneous fMRI/EEG.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Neurobiological impact of nicotinic acetylcholine receptor agonists: an activation likelihood estimation meta-analysis of pharmacologic neuroimaging studies.Biological psychiatry · 2015Pooled it
- Phase IIb Trial of an α7 Nicotinic Receptor Partial Agonist With and Without Nicotine Patch for Withdrawal-Associated Cognitive Deficits and Tobacco Abstinence.Journal of clinical psychopharmacology · 2018Trial
- Individual differences in brain responses to cigarette-related cues and pleasant stimuli in young smokers.Drug and alcohol dependence · 2016Trial
- COMT polymorphism modulates the resting-state EEG alpha oscillatory response to acute nicotine in male non-smokers.Genes, brain, and behavior · 2015Trial
- Altered Regional Brain Activity Underlying the Higher Postoperative Analgesic Requirements in Abstinent Smokers: A Prospective Cohort Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Nicotinic receptor modulation of the default mode network.Psychopharmacology · 2021Article
- 12 h Abstinence-Induced ERP Changes in Young Smokers: Electrophysiological Evidence From a Go/NoGo Study.Frontiers in psychology · 2019Article
- Comparison of local spectral modulation, and temporal correlation, of simultaneously recorded EEG/fMRI signals during ketamine and midazolam sedation.Psychopharmacology · 2018Article
- Nicotine Abstinence Influences the Calculation of Salience in Discrete Insular Circuits.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2018Article
- Using event-related fMRI to examine sustained attention processes and effects of APOE ε4 in young adults.PloS one · 2018Article
- On the Physiological Modulation and Potential Mechanisms Underlying Parieto-Occipital Alpha Oscillations.Frontiers in computational neuroscience · 2018Review
- Targeting neuronal dysfunction in schizophrenia with nicotine: Evidence from neurophysiology to neuroimaging.Journal of psychopharmacology (Oxford, England) · 2017Review
- Combining Multiple Resting-State fMRI Features during Classification: Optimized Frameworks and Their Application to Nicotine Addiction.Frontiers in human neuroscience · 2017Article
- Non-invasive Brain Stimulation for the Treatment of Nicotine Addiction: Potential and Challenges.Neuroscience bulletin · 2016Review
- The effects of nicotine and non-nicotine smoking factors on working memory and associated brain function.Addiction biology · 2016Article
- The motor way: Clinical implications of understanding and shaping actions with the motor system in autism and drug addiction.Cognitive, affective & behavioral neuroscience · 2016Review
- Cortical activity differs during nicotine deprivation versus satiation in heavy smokers.Psychopharmacology · 2015Article
- Working memory-related neural activity predicts future smoking relapse.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Functional Activation during the Rapid Visual Information Processing Task in a Middle Aged Cohort: An fMRI Study.PloS one · 2015Article
- Integrating ecological momentary assessment and functional brain imaging methods: new avenues for studying and treating tobacco dependence.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Impaired attention ('difficulty concentrating') is a cognitive symptom of nicotine withdrawal that may be an important contributor to smoking relapse. However, the neurobiological basis of this effect and the potentially beneficial effects of nicotine replacement therapy both remain unclear. We used functional MRI with simultaneous electroencephalogram (EEG) recording to define brain activity correlates of cognitive impairment with short-term smoking cessation in habitual smokers and the effects of nicotine replacement. We found that irrespective of treatment (ie nicotine or placebo) EEG α power was negatively correlated with increased activation during performance of a rapid visual information processing (RVIP) task in dorsolateral prefrontal, dorsal anterior cingulate, parietal, and insular cortices, as well as, caudate, and thalamus. Relative to placebo, nicotine replacement further increased the α-correlated activation across these regions. We also found that EEG α power was negatively correlated with RVIP-induced deactivation in regions comprising the 'default mode' network (ie angular gyrus, cuneus, precuneus, posterior cingulate, and ventromedial prefrontal cortex). These α-correlated deactivations were further reduced by nicotine. These findings confirm that effects of nicotine on cognition during short-term smoking cessation occur with modulation of neuronal sources common to the generation of both the blood oxygen-level-dependent and α EEG signals. Our observations thus demonstrate that nicotine replacement in smokers has direct pharmacological effects on brain neuronal activity modulating cognitive networks.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.