Trial reportNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2011
Neural correlates of antidepressant-related sexual dysfunction: a placebo-controlled fMRI study on healthy males under subchronic paroxetine and bupropion.
Trial report in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 82 citations in OpenAlex.
- Great Expectations: A Critical Review of and Suggestions for the Study of Reward Processing as a Cause and Predictor of Depression.Biological psychiatry · 2021Pooled it
- The neural basis of sex differences in sexual behavior: A quantitative meta-analysis.Frontiers in neuroendocrinology · 2016Pooled it
- The functional neuroanatomy of male psychosexual and physiosexual arousal: a quantitative meta-analysis.Human brain mapping · 2014Pooled it
- Effects of the glucagon-like peptide-1 receptor agonist dulaglutide on sexuality in healthy men: a randomised, double-blind, placebo-controlled crossover study.EBioMedicine · 2024Trial
- Baseline Perfusion Alterations Due to Acute Application of Quetiapine and Pramipexole in Healthy Adults.The international journal of neuropsychopharmacology · 2016Trial
- Local and Global Resting State Activity in the Noradrenergic and Dopaminergic Pathway Modulated by Reboxetine and Amisulpride in Healthy Subjects.The international journal of neuropsychopharmacology · 2015Trial
- Erotic stimulus processing under amisulpride and reboxetine: a placebo-controlled fMRI study in healthy subjects.The international journal of neuropsychopharmacology · 2014Trial
- Modulation of frontostriatal interaction aligns with reduced primary reward processing under serotonergic drugs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Trial
- The Complex Role Played by the Default Mode Network during Sexual Stimulation: A Cluster-Based fMRI Meta-Analysis.Behavioral sciences (Basel, Switzerland) · 2024Review
- Review
- Psychedelics and sexual functioning: a mixed-methods study.Scientific reports · 2024Article
- Switching to Vortioxetine in Patients with Poorly Tolerated Antidepressant-Related Sexual Dysfunction in Clinical Practice: A 3-Month Prospective Real-Life Study.Journal of clinical medicine · 2024Article
- Effects of bupropion and SSRI antidepressants on leg movement activity and chin muscle tone during sleep in adolescents.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2023Article
- The World Federation of Societies of Biological Psychiatry guidelines on the assessment and pharmacological treatment of compulsive sexual behaviour disorder.Dialogues in clinical neuroscience · 2022Article
- Serotonergic regulation of the dopaminergic system: Implications for reward-related functions.Neuroscience and biobehavioral reviews · 2021Review
- Using pharmacological manipulations to study the role of dopamine in human reward functioning: A review of studies in healthy adults.Neuroscience and biobehavioral reviews · 2021Review
- The role of dopaminergic and serotonergic transmission in the processing of primary and monetary reward.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Article
- Context effects on probability estimation.PLoS biology · 2020Article
- Antidepressant Use During Development May Impair Women's Sexual Desire in Adulthood.The journal of sexual medicine · 2020Article
- Management Strategies for Antidepressant-Related Sexual Dysfunction: A Clinical Approach.Journal of clinical medicine · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sexual dysfunction is a common side effect of selective serotonin reuptake inhibitors (SSRIs) like paroxetine in the treatment of depression, imposing a considerable risk on medication adherence and hence therapeutic success. Bupropion, a norepinephrine and dopamine reuptake inhibitor, is recommended as an alternative treatment without adverse effects concerning sexual arousal and libido. We investigated the neural bases of paroxetine-related subjective sexual dysfunction when compared with bupropion and placebo. We scanned 18 healthy, heterosexual males in a randomized, double-blind, within-subject design while watching video clips of erotic and nonerotic content under steady-state conditions after taking 20 mg of paroxetine, 150 mg of bupropion, and placebo for 7 days each. Under paroxetine, ratings of subjective sexual dysfunction increased compared with placebo or bupropion. Activation along the anterior cingulate cortex (ACC), including subgenual, pregenual, and midcingulate cortices, in the ventral striatum and midbrain was decreased when compared with placebo. In contrast, bupropion let subjective ratings and ACC activations unchanged and increased activity of brain regions including posterior midcingulate cortex, mediodorsal thalamus, and extended amygdala relative to placebo and paroxetine. Brain regions that have been related to the processing of motivational (ventral striatum), emotional, and autonomic components of erotic stimulation (anterior cingulate) in previous studies showed reduced responsiveness under paroxetine in our study. Drug effects on these regions may be part of the mechanism underlying SSRI-related sexual dysfunction. Increased activation under bupropion may point to an opposite effect that may relate to the lack of impaired sexual functioning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.