ArticlePlant physiology2011
Multiple roles of WIN3 in regulating disease resistance, cell death, and flowering time in Arabidopsis.
Article in Plant physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 80 citations in OpenAlex.
- "Bud to bloom"-hormonal coordination in floral initiation.Plant biology (Stuttgart, Germany) · 2025Review
- Role of methylation in vernalization and photoperiod pathway: a potential flowering regulator?Horticulture research · 2023Article
- The flowering time regulator FLK controls pathogen defense in Arabidopsis thaliana.Plant physiology · 2023Article
- GIGANTEA supresses wilt disease resistance by down-regulating the jasmonate signaling inFrontiers in plant science · 2023Article
- GIGANTEA regulatesPlant signaling & behavior · 2022Article
- The role of salicylic acid in plant flower development.Forestry research · 2022Review
- TheFrontiers in plant science · 2022Article
- Modeling first order additive × additive epistasis improves accuracy of genomic prediction for sclerotinia stem rot resistance in canola.The plant genome · 2021Article
- Multi-Omics Analyses Reveal the Regulatory Network and the Function of ZmUGTs in Maize Defense Response.Frontiers in plant science · 2021Article
- Salt Enhances Disease Resistance and Suppresses Cell Death in Ceramide Kinase Mutants.Plant physiology · 2019Article
- LUX ARRHYTHMO mediates crosstalk between the circadian clock and defense in Arabidopsis.Nature communications · 2019Article
- Signalling requirements for Erwinia amylovora-induced disease resistance, callose deposition and cell growth in the non-host Arabidopsis thaliana.Molecular plant pathology · 2018Article
- Article
- Integrated DNA methylome and transcriptome analysis reveals the ethylene-induced flowering pathway genes in pineapple.Scientific reports · 2017Article
- How does the multifaceted plant hormone salicylic acid combat disease in plants and are similar mechanisms utilized in humans?BMC biology · 2017Article
- A Role of the FUZZY ONIONS LIKE Gene in Regulating Cell Death and Defense in Arabidopsis.Scientific reports · 2016Article
- Article
- Partial Activation of SA- and JA-Defensive Pathways in Strawberry upon Colletotrichum acutatum Interaction.Frontiers in plant science · 2016Article
- Differential Roles of Two Homologous Cyclin-Dependent Kinase Inhibitor Genes in Regulating Cell Cycle and Innate Immunity in Arabidopsis.Plant physiology · 2016Article
- Transcriptional Mechanism of Jasmonate Receptor COI1-Mediated Delay of Flowering Time in Arabidopsis.The Plant cell · 2015Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The salicylic acid (SA) regulatory gene HOPW1-1-INTERACTING3 (WIN3) was previously shown to confer resistance to the biotrophic pathogen Pseudomonas syringae. Here, we report that WIN3 controls broad-spectrum disease resistance to the necrotrophic pathogen Botrytis cinerea and contributes to basal defense induced by flg22, a 22-amino acid peptide derived from the conserved region of bacterial flagellin proteins. Genetic analysis indicates that WIN3 acts additively with several known SA regulators, including PHYTOALEXIN DEFICIENT4, NONEXPRESSOR OF PR GENES1 (NPR1), and SA INDUCTION-DEFICIENT2, in regulating SA accumulation, cell death, and/or disease resistance in the Arabidopsis (Arabidopsis thaliana) mutant acd6-1. Interestingly, expression of WIN3 is also dependent on these SA regulators and can be activated by cell death, suggesting that WIN3-mediated signaling is interconnected with those derived from other SA regulators and cell death. Surprisingly, we found that WIN3 and NPR1 synergistically affect flowering time via influencing the expression of flowering regulatory genes FLOWERING LOCUS C and FLOWERING LOCUS T. Taken together, our data reveal that WIN3 represents a novel node in the SA signaling networks to regulate plant defense and flowering time. They also highlight that plant innate immunity and development are closely connected processes, precise regulation of which should be important for the fitness of plants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.