ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2011
Vanilloid, purinergic, and CCK receptors activate glutamate release on single neurons of the nucleus tractus solitarius centralis.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- CCK-expressing neurons in the NTS are directly activated by CCK-sensitive C-type vagal afferents.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- CCK-sensitive C fibers activate NTS leptin receptor-expressing neurons via NMDA receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Brain-gut communication: vagovagal reflexes interconnect the two "brains".American journal of physiology. Gastrointestinal and liver physiology · 2021Review
- Purinergic receptor expression and function in rat vagal sensory neurons innervating the stomach.Neuroscience letters · 2019Article
- Nutritional status-dependent endocannabinoid signalling regulates the integration of rat visceral information.The Journal of physiology · 2017Article
- The Vagus Nerve in Appetite Regulation, Mood, and Intestinal Inflammation.Gastroenterology · 2017Review
- Vagal neurocircuitry and its influence on gastric motility.Nature reviews. Gastroenterology & hepatology · 2016Review
- Localization of TRPV1 and P2X3 in unmyelinated and myelinated vagal afferents in the rat.Journal of chemical neuroanatomy · 2016Article
- Characterization of synapses in the rat subnucleus centralis of the nucleus tractus solitarius.Journal of neurophysiology · 2015Article
- Exposure to a high fat diet during the perinatal period alters vagal motoneurone excitability, even in the absence of obesity.The Journal of physiology · 2015Article
- Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions.Comprehensive Physiology · 2014Review
- Channeling satiation: a primer on the role of TRP channels in the control of glutamate release from vagal afferent neurons.Physiology & behavior · 2014Review
- Roux-en-Y gastric bypass reverses the effects of diet-induced obesity to inhibit the responsiveness of central vagal motoneurones.The Journal of physiology · 2013Article
- A critical re-evaluation of the specificity of action of perivagal capsaicin.The Journal of physiology · 2013Article
- Modulation of gastrointestinal vagal neurocircuits by hyperglycemia.Frontiers in neuroscience · 2013Article
- The unsilent majority-TRPV1 drives "spontaneous" transmission of unmyelinated primary afferents within cardiorespiratory NTS.American journal of physiology. Regulatory, integrative and comparative physiology · 2012Review
- Of apples and oranges: GABA and glutamate transmission in neurones of the nucleus tractus solitarii could not be more different.The Journal of physiology · 2012Article
- TRPV1 marks synaptic segregation of multiple convergent afferents at the rat medial solitary tract nucleus.PloS one · 2011Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Baroreceptor inputs to nucleus of the tractus solitarius medialis (mNTS) neurons can be differentiated, among other features, by their response to vanilloid or purinergic agonists, active only on C- or A-fibers, respectively. A major aim of this study was to examine whether neurons of NTS centralis (cNTS), a subnucleus dominated by esophageal inputs, exhibit a similar dichotomy. Since it has been suggested that cholecystokinin (CCK), exerts its gastrointestinal (GI)-related effects via paracrine activation of vagal afferent C-fibers, we tested whether CCK-sensitive fibers impinging upon cNTS neurons are responsive to vanilloid but not purinergic agonists. Using whole cell patch-clamp recordings from cNTS, we recorded miniature excitatory postsynaptic currents (mEPSCs) to test the effects of the vanilloid agonist capsaicin, the purinergic agonist α,β-methylene-ATP (α,β-Met-ATP), and/or CCK-octapeptide (CCK-8s). α,β-Met-ATP, capsaicin; and CCK-8s increased EPSC frequency in 37, 71, and 46% of cNTS neurons, respectively. Approximately 30% of cNTS neurons were responsive to both CCK-8s and α,β-Met-ATP, to CCK-8s and capsaicin, or to α,β-Met-ATP and capsaicin, while 32% of neurons were responsive to all three agonists. All neurons responding to either α,β-Met-ATP or CCK-8s were also responsive to capsaicin. Perivagal capsaicin, which is supposed to induce a selective degeneration of C-fibers, decreased the number of cNTS neurons responding to capsaicin or CCK-8s but not those responding to α,β-Met-ATP. In summary, GI inputs to cNTS neurons cannot be distinguished on the basis of their selective responses to α,β-Met-ATP or capsaicin. Our data also indicate that CCK-8s increases glutamate release from purinergic and vanilloid responsive fibers impinging on cNTS neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.