ArticleJournal of virology2011
RNA sequence determinants of a coupled termination-reinitiation strategy for downstream open reading frame translation in Helminthosporium victoriae virus 190S and other victoriviruses (Family Totiviridae).
Article in Journal of virology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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37 citing papers in PubMed, 71 citations in OpenAlex.
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- A victorivirus infecting Colletotrichum falcatum: genomic characterization and evolutionary analysis.Archives of virology · 2026Article
- A capsidless (+)RNA yadokarivirus hosted by a dsRNA virus is infectious as particles, cDNA, and dsRNA.Journal of virology · 2025Article
- Molecular characterization of a novel victorivirus isolated from Stagonosporopsis citrulli.Archives of virology · 2024Article
- Identification and characterization of mycoviruses in transcriptomes from the fungal family ceratocystidaceae.Virus genes · 2024Article
- The Expanding Mycovirome ofJournal of fungi (Basel, Switzerland) · 2024Review
- A fijiviral nonstructural protein triggers cell death in plant and bacterial cells via its transmembrane domain.Molecular plant pathology · 2023Article
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- Overlapping genes in natural and engineered genomes.Nature reviews. Genetics · 2022Review
- Novel and diverse mycoviruses co-infecting a single strain of the phytopathogenic fungusFrontiers in cellular and infection microbiology · 2022Article
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- Population Structure of Double-Stranded RNA Mycoviruses That Infect the Rice Blast FungusFrontiers in microbiology · 2020Article
- CHK2-FOXK axis promotes transcriptional control of autophagy programs.Science advances · 2020Article
- Novel Victorivirus from a Pakistani Isolate ofViruses · 2019Article
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- Hiding in plain sight: New virus genomes discovered via a systematic analysis of fungal public transcriptomes.PloS one · 2019Article
- Detection and Molecular Characterization of Novel dsRNA Viruses Related to theFrontiers in cellular and infection microbiology · 2019Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The genome-length, dicistronic mRNA of the double-stranded RNA fungal virus Helminthosporium victoriae virus 190S (genus Victorivirus, family Totiviridae) contains two long open reading frames (ORFs) that overlap in the tetranucleotide AUGA. Translation of the downstream ORF, which encodes the RNA-dependent RNA polymerase (RdRp), has been proposed to depend on ribosomal reinitiation following termination of the upstream ORF, which encodes the capsid protein. In the current study, we examined the RNA sequence determinants for RdRp translation in this virus and demonstrated that a coupled termination-reinitiation (stop-restart) strategy is indeed used. Signals for termination-reinitiation are found within a 32-nucleotide stretch of RNA immediately upstream of the AUGA motif, including a predicted pseudoknot structure. The close proximity in which this predicted structure is followed by the upstream ORF's stop codon appears to be especially important for promoting translation of the downstream ORF. The normal strong preferences for an AUG start codon and the canonical sequence context to favor translation initiation appear somewhat relaxed for the downstream ORF. Similar sequence motifs and predicted RNA structures in other victoriviruses suggest that they all share a related stop-restart strategy for RdRp translation. Members of the genus Victorivirus thus provide new and unique opportunities for exploring the molecular mechanisms of translational coupling, which remain only partly understood in this and other systems.
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