ArticleThe Journal of biological chemistry2011
Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 50 citations in OpenAlex.
- McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation.EMBO reports · 2026Article
- Modelling human adult V-SVZ niche assembly and ependymal cell generation in brain organoids.EMBO reports · 2026Article
- Ependymal and neural stem cells are close relatives.Stem cell reports · 2025Review
- Genetic Primary Microcephalies: When Centrosome Dysfunction Dictates Brain and Body Size.Cells · 2023Review
- GEMC1 and MCIDAS interactions with SWI/SNF complexes regulate the multiciliated cell-specific transcriptional program.Cell death & disease · 2023Article
- Ontogeny of adult neural stem cells in the mammalian brain.Current topics in developmental biology · 2021Review
- Molecular causes of primary microcephaly and related diseases: a report from the UNIA Workshop.Chromosoma · 2020Review
- Transcription factor TAp73 and microRNA-449 complement each other to support multiciliogenesis.Cell death and differentiation · 2019Article
- Article
- Transcriptome analysis of regeneration during Xenopus laevis experimental twinning.The International journal of developmental biology · 2019Article
- Multicilin and activated E2f4 induce multiciliated cell differentiation in primary fibroblasts.Scientific reports · 2018Article
- Controlling centriole numbers: Geminin family members as master regulators of centriole amplification and multiciliogenesis.Chromosoma · 2018Review
- The development and functions of multiciliated epithelia.Nature reviews. Molecular cell biology · 2017Review
- Two Geminin homologs regulate DNA replication in silkworm, Bombyx mori.Cell cycle (Georgetown, Tex.) · 2017Article
- Hyper-Methylated Loci Persisting from Sessile Serrated Polyps to Serrated Cancers.International journal of molecular sciences · 2017Article
- Multiciliated Cells in Animals.Cold Spring Harbor perspectives in biology · 2016Review
- GEMC1 is a critical regulator of multiciliated cell differentiation.The EMBO journal · 2016Article
- GemC1 controls multiciliogenesis in the airway epithelium.EMBO reports · 2016Article
- Mcidas and GemC1/Lynkeas specify embryonic radial glial cells.Neurogenesis (Austin, Tex.) · 2016Article
- The structure of the GemC1 coiled coil and its interaction with the Geminin family of coiled-coil proteins.Acta crystallographica. Section D, Biological crystallography · 2015Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
Development and homeostasis of multicellular organisms relies on an intricate balance between cell proliferation and differentiation. Geminin regulates the cell cycle by directly binding and inhibiting the DNA replication licensing factor Cdt1. Geminin also interacts with transcriptional regulators of differentiation and chromatin remodelling factors, and its balanced interactions are implicated in proliferation-differentiation decisions during development. Here, we describe Idas (Idas being a cousin of the Gemini in Ancient Greek Mythology), a previously uncharacterised coiled-coil protein related to Geminin. We show that human Idas localizes to the nucleus, forms a complex with Geminin both in cells and in vitro through coiled-coil mediated interactions, and can change Geminin subcellular localization. Idas does not associate with Cdt1 and prevents Geminin from binding to Cdt1 in vitro. Idas depletion from cells affects cell cycle progression; cells accumulate in S phase and are unable to efficiently progress to mitosis. Idas protein levels decrease in anaphase, whereas its overexpression causes mitotic defects. During development, we show that Idas exhibits high level expression in the choroid plexus and the cortical hem of the mouse telencephalon. Our data highlight Idas as a novel Geminin binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.