ArticleEnvironmental health perspectives2011
An approach for quantitatively balancing methylmercury risk and omega-3 benefit in fish consumption advisories.
Article in Environmental health perspectives, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Assessment of dietary fish consumption in pregnancy: comparing one-, four- and thirty-six-item questionnaires.Public health nutrition · 2014Trial
- Community assessment of fish consumption and methyl mercury exposure among Asian women of reproductive age in Chicago.Journal of exposure science & environmental epidemiology · 2026Article
- Exposome-wide association study of cognition among older adults in the National Health and Nutrition Examination Survey.Exposome · 2025Article
- Exposome-wide association study of cognition among older adults in the National Health and Nutrition Examination Survey.medRxiv : the preprint server for health sciences · 2024Article
- Article
- Geohealth Policy Benefits Are Mediated by Interacting Natural, Engineered, and Social Processes.GeoHealth · 2023Article
- Balancing the health effect between risks of methylmercury and benefits of nutrients in consumption of Chinese mitten crab (Eriocheir sinensis) in China.Environmental science and pollution research international · 2022Article
- Risk-Benefit Modeling to Guide Health Research in Collaboration with Great Lakes Fish Consuming Native American Communities.Journal of Great Lakes research · 2020Article
- Mercury, Polychlorinated Biphenyls, Selenium, and Fatty Acids in Tribal Fish Harvests of the Upper Great Lakes.Risk analysis : an official publication of the Society for Risk Analysis · 2018Article
- Maternal intake of seafood and supplementary long chain n-3 poly-unsaturated fatty acids and preterm delivery.BMC pregnancy and childbirth · 2017Article
- Role of fruits, grains, and seafood consumption in blood cadmium concentrations of Jamaican children with and without Autism Spectrum Disorder.Research in autism spectrum disorders · 2014Article
- Article
- Selenium and mercury molar ratios in commercial fish from New Jersey and Illinois: variation within species and relevance to risk communication.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2013Article
- Associations of blood and urinary mercury with hypertension in U.S. adults: the NHANES 2003-2006.Environmental research · 2013Article
- Seafood consumption and blood mercury concentrations in Jamaican children with and without autism spectrum disorders.Neurotoxicity research · 2013Article
- Which fish should I eat? Perspectives influencing fish consumption choices.Environmental health perspectives · 2012Review
- Selenium and mercury molar ratios in saltwater fish from New Jersey: individual and species variability complicate use in human health fish consumption advisories.Environmental research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNearly all fish consumption advisories for methylmercury (MeHg) are based only on risk. There is a need to also address benefits, especially those from polyunsaturated fatty acids (PUFAs), in neurodevelopmental function and cardiovascular health. However, because MeHg and PUFA generally act on these same end points, disentangling risk and benefit is challenging.
objectivesWe propose an approach for balancing risk and benefit that is based on the use of statistically dissociated measures of risk and benefit. DISCUSSION: Because of mutual coexposure of MeHg and PUFAs in population-based studies and their opposite effect on many of the same end points, MeHg risk and PUFA benefit are tightly linked statistically, which results in mutual (negative) confounding. Thus, neither MeHg risk nor PUFA benefit can be accurately quantified without taking the other into account. A statistical approach that generates unconfounded risk and benefit coefficients for each end point can permit their subsequent recombination to describe the overall risk-benefit profile of each species of fish or fish diet. However, it appears that some end points may be adversely affected by MeHg without experiencing counterbalancing benefit from PUFAs. Such end points may drive consumption advisories and may preclude balancing of risk and benefit on the basis of other end points.
conclusionsOur thinking about fish consumption advisories now recognizes the need to balance risk and benefit. However, although statistical analysis of the appropriate data can eliminate mutual confounding, care is required to address the most sensitive end points that may be sensitive to risk and not benefit.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.